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Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.
Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.
Preface xi
1 Introduction and Overview 1
I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11
2 The Search for Progress and a New Theory Framework in Cancer Research 13
3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41
II THE SYSTEMS DIMENSION OF CANCER 61
4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63
5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129
6 Adaptation of Molecular Interaction Networks in Cancer Cells 141
7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163
III THE TIME DIMENSION OF CANCER 185
8 Darwinism, Not Mutationalism, for New Cancer Therapies 187
9 Cancer as a Reversion to an Ancestral Phenotype 205
10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227
IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245
11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247
12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271
13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299
14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323
15 Niche Reconstruction to Revert or Transcend the Cancer State 353
V WHAT NEXT? 391
Contributors 397
Index 399
| Erscheinungsjahr: | 2021 |
|---|---|
| Fachbereich: | Andere Fachgebiete |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Seiten: | 376 |
| Inhalt: | Einband - fest (Hardcover) |
| ISBN-13: | 9780262045216 |
| ISBN-10: | 0262045214 |
| Sprache: | Englisch |
| Einband: | Gebunden |
| Autor: |
Strauss, Bernhard
Bertolaso, Marta |
| Redaktion: |
Bernhard Strauss
Marta Bertolaso Ingemar Ernberg Mina J. Bissell |
| Besonderheit: | Unsere Aufsteiger |
| Hersteller: | MIT Press Ltd |
| Maße: | 237 x 188 x 35 mm |
| Von/Mit: | Bernhard Strauss (u. a.) |
| Erscheinungsdatum: | 27.04.2021 |
| Gewicht: | 0,945 kg |
Preface xi
1 Introduction and Overview 1
I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11
2 The Search for Progress and a New Theory Framework in Cancer Research 13
3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41
II THE SYSTEMS DIMENSION OF CANCER 61
4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63
5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129
6 Adaptation of Molecular Interaction Networks in Cancer Cells 141
7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163
III THE TIME DIMENSION OF CANCER 185
8 Darwinism, Not Mutationalism, for New Cancer Therapies 187
9 Cancer as a Reversion to an Ancestral Phenotype 205
10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227
IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245
11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247
12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271
13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299
14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323
15 Niche Reconstruction to Revert or Transcend the Cancer State 353
V WHAT NEXT? 391
Contributors 397
Index 399
| Erscheinungsjahr: | 2021 |
|---|---|
| Fachbereich: | Andere Fachgebiete |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Seiten: | 376 |
| Inhalt: | Einband - fest (Hardcover) |
| ISBN-13: | 9780262045216 |
| ISBN-10: | 0262045214 |
| Sprache: | Englisch |
| Einband: | Gebunden |
| Autor: |
Strauss, Bernhard
Bertolaso, Marta |
| Redaktion: |
Bernhard Strauss
Marta Bertolaso Ingemar Ernberg Mina J. Bissell |
| Besonderheit: | Unsere Aufsteiger |
| Hersteller: | MIT Press Ltd |
| Maße: | 237 x 188 x 35 mm |
| Von/Mit: | Bernhard Strauss (u. a.) |
| Erscheinungsdatum: | 27.04.2021 |
| Gewicht: | 0,945 kg |
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