1. Introduction.- Part I: Menopausal hormone therapy in women.- 2. Consequences of oestradiol deficiency in menopausal women.- 3. Menopausal hormone therapy and prevention of chronic disease.- 4. Menopausal hormone therapy in primary care. Benefits, risks, and how to tailor the dose.- 5. Menopausal hormone therapy and prevention of cardiovascular disease.- 6. Menopausal hormone therapy and diabetes.- 7. Menopausal hormone therapy and cognition: An opportunity for precision medicine.- 8. Menopause hormone therapy in chronic auto-immune, pulmonary, and neurodegenerative diseases.- 9. Current concepts in menopausal hormone therapy and breast cancer.- 10. Progesterone and progestins in women s health.- 11. Testosterone therapy in menopausal women with sexual dysfunction: 1940-2024.- 12. Testosterone therapy and metabolic health in menopausal women.- Part II. Testosterone therapy in hypogonadal men.- 13. Impact of testosterone deficiency and therapy on men s health.- 14. History of testosterone therapy in men with testosterone deficiency.- 15. Testosterone therapy in men with functional hypogonadism.- 16. Male testosterone deficiency and therapy in primary care.- 17. Long-term effects of testosterone therapy in men with testosterone deficiency.- 18. Hypogonadism in men with obesity and diabetes.- 19. Testosterone therapy and prevention of type 2 diabetes in men with hypogonadism.- 20. Testosterone therapy and cardiovascular health.- 21. Testosterone therapy and the prostate.- 22. Benefits of testosterone therapy on mood and well-being.- 23. Testosterone deficiency and benefits of testosterone therapy in male veterans.- Part III. Thyroid and growth hormone therapy.- 24. Precision thyroid hormone therapy for hypothyroidism.- 25. Growth hormone deficiency and therapy during aging.