Reuven Zimlichman is Chief of the Department of Medicine, Head of the Hypertension Institute at the E. Wolfson Medical Center, Israel, Director of 'The Brunner Cardiovascular Research Institute', Tel-Aviv University and Director of the 'Institute for Quality in Medicine', Israeli Medical Association. He is also a former Vice Dean and Head of School of the Continuing Education program at the Sackler Faculty of Medicine, Tel Aviv University. Zimlichman has published more than 200 papers, 5 books and numerous book chapters. His publications are in the fields of basic research, cell cultures, animal research and clinical research and cover clinical areas including hypertension, cardiovascular disease, metabolic syndrome, end organ damage and evaluation of arterial properties.

Giuseppe Mancia is a Professor Emeritus of the University of Milano-Bicocca and served as Professor of Medicine and Head of the First Division of Medicine at the San Gerardo Hospital, Italy. He is executive officer of the European Society of Hypertension and Chair of the ESH Educational Committee. Mancia's research interests are focused on the pathophysiology, diagnosis and therapy of hypertension, heart failure, coronary and other cardiovascular diseases. His fields of expertise include ambulatory blood pressure monitoring, neural control of circulation, large artery mechanics, and clinical trials.

Provides valuable guidance for identifying which asymptomatic pre-hypertensive subjects could profit from being appropriately screened and treated

Fills a knowledge gap and lays the groundwork for developing recommendations and guidelines

Will benefit cardiologists, primary care physicians and all those healthcare professional looking to optimally manage these complex and often-undiagnosed cases

I Epidemiology and Statistics.- 1 Epidemiology, statistics and health burden.- 2 PreHypertension, the risk of Hypertension and events.- 3 Parental history of hypertension as the determinant of cardiovascular function.- 4 High normal blood pressure in children and adolescents.- II Pathophysiology of prehypertension.­- Part 1 Alteration of Cardiovascular control systems.- 5 Tachycardia in PreHypertension.- 6 Endothelial dysfunction in early phases of hypertension.- 7 Prehypertension and the Renin angiotensin aldosterone system.- 8 The role of the brain in neurogenic prehypertension.- 9 The blood pressure seeking property of the brain.- Part 2 Organ damage in Prehypertension.- 10 Microvascular structural alternations and tissue perfusion in hypertension and diabetes.-11 The heart in prehypertension.- 12 The role of the kidney in PreHypertension.- 13 Obesity, Hypertension and Chronic Kidney Disease: A Forty Year Retrospective.- 14 Pre-CKD? Early markers of renal dysfunction in patientswith Prehypertension.- 15 Arterial stiffness in early phases of Prehypertension.- 16 The role of perivascular fat in raising blood pressure in obesity and diabetes.- 17 The Brain.- 18 Diurnal and pulsatile hemodynamics in individuals with PreHypertension.- 19 Systolic hypertension in youth.- 20 Prehypertension and ethnicity: Haemodynamic mechanisms in young adults.- 21 Hemodynamics (systemic and renal) in prehypertension.- 22 Central blood pressure and Prehypertension.- Section 3: Risk assessment in PreHypertension.- 23 Blood pressure measurement, white coat and masked hypertension.-24 Vascular functional and structural risk assessment in prehypertension.- 25 Blood pressure variability.- 26 Morning Surge of Blood Pressure.- 27 Role of ambulatory Blood Pressure Monitoring in Prehypertension.- 28 Home blood pressure, prehypertension and hypertension.- 29 Blood pressure and atherosclerosis- subclinical arteriosclerosis as an early sign of organ damage.- 30 Response to stress, effortand cold pressor test as predictors of Prehypertension.- 31 Physical Activity and Exercise Training as Important Modifiers of Vascular Health.- 32 Prehypertension and associated metabolic risk factors.- IV End organ damage in PreHypertension.- 33 Early cardiovascular dysfunction in Prehypertension.- 34 Effect of blood pressure lowering in hypertensive rats.- V Clinical studies in PreHypertension.- 35 Review of "old and new studies" in the treatment of PreHypertension.- 36 The CHINON study- argument for early treatment of PreHypertension. Effect of age on progression of hypertension.- 37 The PREVER study.- 38 The TROPHY study.- VI Management of PreHypertension.- 39 Non-pharmacologic approaches for the management of prehypertension.- 40 Antihypertensive drugs and vascular health.- 41 Prehypertension: a case in favor of early use of diuretics.- 42 Treatment of High normal blood pressure in the guidelines.- VII Tentative additional chapters.- 43 History of prehypertension: a saga of misunderstanding and neglect.- 44 Management of Prehypertension and hypertension in women of reproductive age.