Nathan I. Cherny is Norman Levan Chair of Humanistic Medicine at Shaare Zedek Medical Center and Associate Professor of Medicine at Ben Gurion University, Israel. In 2015 he was awarded the ESMO (European Society of Medical Oncology) Award for his contributions to the development of oncology in Europe, and in 2016 was the recipient of the EAPC/EJPC (European Association of Palliative Care/ European Journal of Palliative Care) Palliative Care Policy Development Award. Nathan has diverse research interests including opioid responsiveness of neuropathic pain, opioid rotation, opioid side effects and their management, cancer pain syndromes, suffering, palliative sedation, communication issues in oncology and palliative care, bioethics, and public health. He teaches in the Hebrew University Medical School and runs courses in communication and palliative medicine. Nathan has edited five books and has published over 120 peer reviewed papers and has made numerous invited lectures worldwide.

Marie T. Fallon is the St Columba's Hospice Chair of Palliative Medicine at the University of Edinburgh, Honorary Consultant in Palliative Care at the Western General Hospital in Edinburgh and leads the Edinburgh Palliative and Supportive Care group (EpaS). Marie serves as Chief Investigator for EpaS on a large portfolio of clinical studies spanning investigator-led randomized controlled trials examining improved management of cancer-induced bone pain, neuropathic pain, and institutionalisation of pain assessment. Marie is also the lead in an international programme of RCTs in cannabinoids in cancer-related pain and has led the development of studies using fMRI in Edinburgh, UK.

Stein Kaasa is Professor of Palliative Medicine at the Institute of Cancer Research and Molecular Medicine at the Norwegian University of Science and Technology (NTNU), Norway. Stein specialises in medical oncology, radiotherapy, and palliative medicine. In 1993, he was appointed as the first professor in palliative medicine in Scandinavia and he was one of the founders of the palliative care unit in Trondheim and founder of the European Palliative Care Research Centre (PRC). He has been president of EAPC, the coordinator for a large EU-funded project, and is at present involved in several research collaborative and international partnerships on research and policy development. Stein has been an important advocate for evidence-based practice and has worked extensively to get palliative care research on the global agenda. Stein is also Director of the PRC and Chair of the European Association for Palliative Care Research Network and has published more than 450 articles and book chapters.

Russell K. Portenoy is Executive Director and Chief Medical Officer of the MJHS Institute for Innovation in Palliative Care and is Professor of Neurology and Family and Social Medicine at the Albert Einstein College of Medicine, New York. Prior to joining MJHS, he was founding Chairman of the Department of Pain Medicine and Palliative Care and the Gerald J. Friedman Chair in Pain Medicine and Palliative Care at Mount Sinai Beth Israel Medical Center. Russell is Past President of both the American Academy of Hospice and Palliative Medicine and the American Pain Society. He previously chaired the American Board of Hospice and Palliative Medicine. Russell is recipient of the Lifetime Achievement Award, the National Leadership Award of the American Academy of Hospice and Palliative Medicine, the Wilbert Fordyce Award for Lifetime Excellence in Clinical Investigation, the Distinguished Service Award from the American Pain Society, and the Founder's Award by the American Academy of Pain Medicine.

David C. Currow is Professor of Palliative Medicine at University of Technology Sydney, the Matthew Flinders Distinguished Professor of Palliative and Supportive Care, Flinders University and Associate Director (Research) at the Wolfson Palliative Care Research Centre, University of Hull, UK. Research includes clinical trials and use of large datasets to understand better the impact of life-limiting illnesses on patients and caregivers. Research into chronic breathlessness is a particular area of interest. He is the principal investigator for the Australian national Palliative Care Clinical Studies Collaborative (PaCCSC) and is a foundation partner in the Australian national Palliative Care Outcomes Collaborative (PCOC), an initiative to improve palliative care clinical outcomes through point-of-care data collection.

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• Section 1: The worldwide status of palliative care


• 1.1: Carlos Centeno, Sheila Payne, and Eduardo Garralda: International progress in the development of palliative medicine


• 1.2: Lukas Radbruch and Liliana De Lima: Essential medicines for palliative care


• 1.3: Frank Brennan and Liz Gwyther: Human rights issues


• 1.4: Stephen R. Connor: Policy in palliative care


• Section 2: The challenge of palliative medicine


• 2.1: Russell K. Portenoy: Building definitional consensus in palliative care


• 2.2: Nathan I. Cherny and Russell K. Portenoy: Core concepts in palliative care


• 2.3: Davinia Seah, David Marco, Jennifer Philip, and Megan B. Sands: The epidemiology of death and symptoms: Planning for population-based palliative care


• 2.4: Barry Laird, Erna Haraldsdottir, and Charlie Hall: Barriers to the delivery of palliative care


• 2.5: Jonathan Koffman and Natalia Calanzani: Ethnic and cultural aspects of palliative and end of life care


• 2.6: Peter S. Hall, Katharina Diernberger, and Liz Grant: Health economics for palliative care


• Section 3: Service delivery issues in palliative care


• 3.1: Breffni Hannon, Stein Kaasa, and Camilla Zimmermann: Specialist palliative care along the trajectory of illness: Issues in the early integration of palliative care


• 3.2: Irene J. Higginson: Palliative care delivery models


• 3.3: Sharon Einav, Nathan I. Cherny, and J. Randall Curtis: Palliative medicine in the intensive care unit


• 3.4: Naomi George and Corita Grudzen: Palliative care in the emergency department


• 3.5: Jane Phillips and Annmarie Hosie: Palliative care in the nursing home


• Section 4: Healthcare professionals in palliative care


• 4.1: Dagny Faksvåg Haugen, Friedemann Nauck, and Deborah Witt Sherman: The core team and the extended team


• 4.2: Nathan I. Cherny, Batsheva Werman, and Michael Kearney: Burnout, compassion fatigue, and moral distress in palliative care


• 4.3: Betty R. Ferrell, Polly Mazanec, Pam Malloy, and Rose Virani: Nursing Education in palliative care


• 4.4: Terry Altilio, Bridget Sumser, and Nina Laing: Social work in palliative care


• 4.5: George Handzo and Christina Puchalski: The role of the chaplain in palliative care


• 4.6: Maria Denise Pessoa Silva, Fiona Rolls, Lynne White, Tamsin Longley, Jane Murphy, and Jill Cooper: Occupational therapy in palliative care


• 4.7: Nigel Hartley: The role of the creative arts in palliative care


• 4.8: Samantha Cushen and Aoife Ryan: The role of the dietitian in palliative care


• 4.9: Lucy Fettes and Matthew Maddocks: Physiotherapy in palliative care


• 4.10: Tim Luckett and Katherine L.P. Reid: Speech and language therapy in palliative care


• 4.11: E. Alessandra Strada: Clinical psychology in palliative care


• 4.12: Ebtesam Ahmed: The contribution of the clinical pharmacist in palliative care


• 4.13: Andrew Malcom Cole: Medical rehabilitation and the palliative care patient


• Section 5: Communication and palliative medicine


• 5.1: Thomas LeBlanc and James Tulsky: Communication with the patient and family


• 5.2: Susan D. Block: Practical considerations including difficult conversations


• 5.3: Judith Rietjens, Ida Korfage, and Jane Seymour: Advance care planning


• Section 6: Family and caregiver issues


• 6.1: Carrie Lethborg and David W. Kissane: Family dynamics in the context of serious illness


• 6.2: Rinat Nissim, Sarah Hales, and Gary Rodin: Caregiver burden and distress


• Section 7: Pain


• 7.1: Lucy N. Wyld, Clare Rayment, and Mike I. Bennett: Definition and assessment of chronic pain in advanced disease


• 7.2: Anthony H. Dickenson and Richard Gordon-Williams: Pathophysiology of pain in cancer and other terminal illnesses


• 7.3: Nathan I. Cherny: Acute cancer pain syndromes


• 7.4: Nathan I. Cherny: Chronic cancer pain syndromes


• 7.5: Ruth Miles, Steven Wanklyn, and Joy Ross: Principles of drug therapy


• 7.6: Nathan I. Cherny and Marie T. Fallon: Opioid therapy: Optimizing analgesic outcomes


• 7.7: Joseph V. Pergolizzi, Jr., Jo Ann LeQuang, Flaminia Coluzzi, Dean Mariano, Andrew Nicolaou, and Christopher Gharibo: Opioid therapy: Managing risks of abuse, addiction, and diversion


• 7.8: Per Sjøgren, Frank Elsner, and Stein Kaasa: Non-opioid analgesics


• 7.9: Ebtesam Ahmed, Russell K. Portenoy, and Mona Patel: Adjuvant analgesics: principles of use


• 7.10: Robert A. Swarm, Menelaos Karanikolas, Lesley K. Rao, and Rajiv K. Shah: 7.10 Interventional approaches for chronic pain


• 7.11: Helena Knotkova: Neurostimulation in pain management


• 7.12: Joseph Winger, Carolyn E. Keeler, and Francis Keefe: Behavioral and psychosocial interventions for pain management


• 7.13: Noah Samuels and Eran Ben-Arye: Integrative medicine therapies in pain management


• 7.14: Peter Hoskin: Management issues in bone pain


• 7.15: Nanna Finnerup and Lise Ventzel: Management issues in neuropathic pain


• 7.16: Victor T. Chang: Management issues in visceral pain


• 7.17: Judith A. Paice: Management issues in chronic pain following cancer therapy


• 7.18: Renee McCulloch: Paediatric pain control


• Section 8: Gastrointestinal symptoms and disorders


• 8.1: Katherine Clark: Dysphagia, dyspepsia, and hiccups


• 8.2: Saskie Dorman: Nausea and vomiting


• 8.3: Philip J. Larkin: Constipation and diarrhoea


• 8.4: Alexandra Shingina and Anne M. Larson: Jaundice, ascites, and encephalopathy


• 8.5: Vickie Baracos and Sharon Watanabe: Aetiology, classification, assessment, and treatment of the anorexia-cachexia syndrome


• 8.6: Jann Arends and Florian Strasser: Parenteral nutrition


• Section 9: Cardio-respiratory symptoms and disorders


• 9.1: Miriam Johnson and David C. Currow: Breathlessness and other respiratory symptoms in palliative care


• 9.2: Doris Tse and Kin-Sang Chan: Cough and other pulmonary symptoms


• Section 10: Skin and oral symptoms and disorders


• 10.1: Sebastian Probst and Georgina Gethin: Skin problems in palliative care


• 10.2: Charles P. Tilley, Mei R. Fu, Janet H. Van Cleave, Allison R. Most, and Christopher Comfort: Palliative wound and ostomy care


• 10.3: Vaughan Keeley: Lymphoedema and oedema of advanced disease


• 10.4: Andrew N. Davies: Oral care


• Section 11: Genitourinary symptoms and disorders


• 11.1: Christopher Evans, Jennifer G. Rothschild, Noah Canvasser, and Frederick Meyers: Dysuria, frequency, and bladder spasm


• 11.2: Noah E. Canvasser, Jennifer G. Rothschild, Frederick J. Meyers and Christopher P. Evans: Obstructive urinary disorders


• Section 12: Constitutional symptoms and related disorders


• 12.1: Sriram Yennurajalingam and Eduardo Bruera: Fatigue


• 12.2: Lauren Kadwell, Jane Ussher, Emilee Gilbert, Janette Perz, and Amanda Hordern: Sexuality in palliative care: Discussing patient sexuality and intimacy in palliative care


• 12.3: Kyriaki Mystakidou, Efi Parpa, and Eleni Tsilika: Sleep disorders


• 12.4: Simon Noble, Nicola Pease, and Nicholas Chinn-Yee: Assessment and management of thrombotic complications


• 12.5: Bill Hulme, Sarah Wilcox, Paul Ashwood, Laura Deacon, Hazel Gilkes, and Victoria Montgomery: Assessment and management of bleeding complications in the medically ill


• Section 13: Psychiatric and psychological symptoms and disorders


• 13.1: Tzeela Cohen and Simon Wein: Coping and resilience in palliative medicine


• 13.2: David W. Kissane: Depression, demoralization, and suicidality


• 13.3: Kerry A. Sherman and Christopher J. Kilby: Fear, anxiety, and adjustment disorder in palliative care


• 13.4: Meera Agar, Yesne Alici, Augusto Caraceni, and William Breitbart: Delirium


• 13.5: David W. Kissane: Bereavement


• Section 14: Palliative care in cancer


• 14.1: Nathan I. Cherny and Stein Kaasa: The oncologist s role in delivering palliative care


• 14.2: Olav Dajani and Karin Jordan: Disease-modifying therapies in advanced cancer-medical treatment


• 14.3: Peter Hoskin: Radiotherapy in symptom management


• 14.4: Robert Krouse and Brian Badgwell: The role of general surgery in the palliative care of patients with cancer


• 14.5: Mohamed Yakoub and John Healey: Orthopaedic surgery in the palliation of cancer


• 14.6: Eran Ben Arye and Noah Samuels: Integrative oncology in palliative medicine


• 14.7: Tarun Sabharwal, Nicos I. Fotiadis, and Andy Adam: Interventional radiology in the palliation of cancer


• 14.8: Augusto Caraceni, Fabio Simonetti, and Cinzia Martini: Neurological problems in advanced cancer


• 14.9: Richella Ryan and Ruth Casey: Endocrine and metabolic complications of advanced cancer


• 14.10: Jason W. Boland and Elaine G. Boland: Malignant Bowel obstruction


• 14.11: Catriona Mayland and Simon N. Rogers: Palliative care issues in head and neck cancers


• 14.12: Thomas William LeBlanc and Arjee El-Jawahri: Palliative care issues in populations with haematological malignancies


• 14.13: Nancy Zhu and Cynthia Wu: Anaemia,...