Hiromu Yawo MD PhD

Reviews all aspects of optogenetics

Explains applications in neuroscience and medicine

Examines emerging directions in the field

Part 1. Light-sensitive channels and transporters.- 1. History and Perspectives of Light-Sensing Proteins.- 2. Phototactic behavior of Chlamydomonas.- 3. Structure-Functional Analysis of rhodopsin light sensors.- 4. Molecular Dynamics of Channelrhodopsin.- 5. Photochemistry of Halorhodopsin.- 6. Spectroscopic Dynamics of Microbial Rhodopsins.- 7. Molecular Engineering of Retinylidene Proteins.- 8. A new optogenetic tools from deep ocean.- Part 2. Light-sensitive signaling molecules.- 9. Biology of Light-Sensing Proteins in Plants and Microorganisms.- 10. Optogenetic Potentials of Diverse Animal Opsins.- 11. Enzyme rhodopsins.- 12.Optogenetic photoswitches.- 13.Genetic, biochemical and biophysical studies on flavoprotein photoreceptors.- Part 3. Optogenetics in Biological System.- 14. General Description: Future Prospects of Optogenetics.- 15. Optogenetic Manipulation and Probing.- 16. Visualization and Manipulation Signaling Molecules In Vivo.- 17. Optical Manipulation of Gene Expression.- 18. Optical Manipulation of Intracellular Signaling.- 19. Single Molecule Optogenetics.- 20. Bioluminescence Imaging.- 21. Luminescence Optogenetics.- 22. Optogenetic Imaging of Protein Activity in the Synapse Using 2-Photon Fluorescence Lifetime Imaging Microscopy.- 23. Optogenetics in Drosophila.- 24. Optogenetics in Caenorhabditis elegans.- 25. Optogenetics in zebrafish.- 26. Optogenetics Research Using the Mouse as a Model System.- 27. Optogenetics Research Using Rat.- 28. Optogenetics Research Using Primates.- 29. Organelle Optogenetics.- Part 4. Optogenetics in Neuroscience.- 30. Neuroscientific Frontline of Optogenetics.- 31. Elucidation of Neuronal Circuitry Involved in the Regulation of Sleep/Wakefulness Using Optogenetics.- 32. Multiscale neural activity in the behaving brain.- 33. Optogenetic Analysis of Striatal Connections to Determine Functional Connectomes.- 34. Optogenetics for the Behavior Manipulation of Non-human Primates.- 35. Activity Regulation in the Study of Neural Plasticity.- 36. Optogenetic Control of Synaptic Plasticity.- 37. Casting Light on the Role of Glial Cells in Brain Function.- 38. Optogenetic manipulation of Respiratory Rhythm.- 39. Optogenetic mapping of brain circuitry.- 40. In vivo imaging of Arc transcription.- 41. Neural Circuits for the Formation and Retrieval of Episodic Memories.- Part 5. Medical Optogenetics.- 42. Medical Optogenetics, Overview.- 43. Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders.- 44. Gene Therapy Using Channelrhodopsins to Treat Blindness.- 45. Optogenetic Approaches to Restoring Intrinsic Visual Processing Features in Retinal Ganglion Cells.- 46. Application of optogenetics to epilepsy research.- Part 6. Opto-electro-nano Technologies for Optogenetics.- 47. CMOS-Based Neural Interface Device for Optogenetics.- 48. OLED System for Optogenetics.- 49. Micro-imaging probes, Opto-electrodes, and Virtual Reality Systems for Optogenetics.- 50. Upconversion.- 51. Optical probes for in vivo optogenetics.