State of the art report on neutron capture therapy

Summarizes the progress made in recent decades

Multidisciplinary approach

Written by the most experienced specialists

Includes supplementary material: [...]

Includes supplementary material: [...]

Part I: Neutron sources: Fission Reactor Based Irradiation Facilities for Neutron Capture Therapy.- Accelerator-Based BNCT.- Compact Neutron Generator for BNCT.- Californium-252 as a neutron source for BNCT.- Part II: Boron: Boron Chemistry.- New Candidates for Boron Carriers in BNCT.- Drugs for BNCT (BSH and BPA).- Part III: Analysis and Imaging: Boron analysis and Boron Imaging.- Proteomic investigations for Boron Neutron Capture Therapy.- Analysis and Imaging: PET.- Localized quantitative detection and imaging of Boron by Magnetic Resonance.- Part IV: Physics: Boron Neutron Capture Therapy: Application of Radiobiological Principles.- Tolerance of Healthy Tissues and Ideal Radiation Dose on BNCT.- Part VI: Clinical Applications: Clinical trials in BNCT ¿ a challenging task.- External beam BNCT for Glioblastoma mulitforme.- Clinical results of sodium borocaptate (BSH)-based intra-operative boron neutron capture therapy (IO-BNCT).- Boron neutron capture therapy for malignant meningiomas.- Feasibility for intramedullary spinal glioma.- BNCT for Advanced or Recurrent Head and Neck Cancer.- Studies on the possible application of BNCT to thyroid cancer.- Malignant Melanoma.- Application of Neutron Capture Therapy for Local Recurrenced Breast Cancer.- Recurrent breast cancers & inflammatory breast cancers.- Liver Metastases.- Boron Neutron Capture Therapy for Children with Malignant Brain Tumors.- Part VII: Non malignant diseases: Prevention of vascular restenosis after vascular angioplasty.-Boron Neutron Capture Synovectomy.- Managerial Aspects of BNCT at a nuclear research reactor.