In his career he engaged in three-phase reactor development; fixed bed, moving bed, biomass fermentation to ethanol, xanthan gum fermentation, fluid bed shale oil retorting, heat transfer in fluid beds, three-phase reactive distillation de-bottlenecking, crystallization start-up optimization by dynamic modelling, reactive distillation, and dividing wall distillation.

Since 2010 he is an independent consultant for Harmsen Consultancy, providing advice, and courses on: sustainable product and process innovation, sustainable product and process concept design, process intensification concept design, industrial process scale-up, and industrial unit operations scale-up. He is (co) author of several books and articles.

René Bos is currently Senior Principal Science Expert within the department Long Range Research and Experimentation at Shell Projects & Technology, Amsterdam. Since June 2018 he is part time (0.2 fte) seconded to Ghent University as guest professor "Industrial Reaction Engineering" at the Laboratory of Chemical Technology (LCT). He received his PhD in chemical engineering at University Twente on "Reactor and catalyst dynamics and stability" in the group of Prof. Roel Westerterp.

He joined Shell in September 1991 where he has had a variety of roles in Amsterdam, Pernis and Houston, mostly within R&D but also at manufacturing sites. In these roles he worked in wide variety of (reactor) technology fields, including ethylene oxide, DeNOx, MTO, SM/PO, Fischer-Tropsch, Gas-to-Chemicals, E-ODH, OCM, syngas technologies and CO2 conversions, spanning the whole range from ideation, proof of concept, development and pilot plant testing to deployment.

In 2018 he was appointed guest professor at Ghent University. Overall, he (co-) authored 40 scientific publications in the open literature (next to >100 Shell internal research reports) and 42 Patent Applications.