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Molecular Science of Fluctuations Toward Biological Functions
Buch von Mazahide Terazima (u. a.)
Sprache: Englisch

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Beschreibung
In this monograph, the importance of fluctuations for
biological reactions is discussed from various points of view. Understanding
the biological reactions at the molecular level is one of the major targets in
many scientific fields, including not only basic biology but also physics,
physical chemistry, and medical science. One of the key factors in the process
is ¿fluctuation¿. Thermal energy causes biological molecules to be in constant
fluctuation even while they are carrying out their biological functions. How do
biological systems overcome the thermal fluctuations to realize the
physiologically relevant reactions? Scientists in a number of fields¿physics,
chemistry, pharmacology, medicine, and others¿have contributed chapters that
elucidate the nature of the fluctuations and the relationship between
fluctuations and biological functions. The fluctuations discussed in this volume
are detected by the transient grating method, nuclear magnetic resonance, X-ray
diffraction and scattering, and computer simulation, among other methods. The
book presents various results of the studies of fluctuations in biological
processes that were obtained with these methods by the leading scientists in
their fields.
In this monograph, the importance of fluctuations for
biological reactions is discussed from various points of view. Understanding
the biological reactions at the molecular level is one of the major targets in
many scientific fields, including not only basic biology but also physics,
physical chemistry, and medical science. One of the key factors in the process
is ¿fluctuation¿. Thermal energy causes biological molecules to be in constant
fluctuation even while they are carrying out their biological functions. How do
biological systems overcome the thermal fluctuations to realize the
physiologically relevant reactions? Scientists in a number of fields¿physics,
chemistry, pharmacology, medicine, and others¿have contributed chapters that
elucidate the nature of the fluctuations and the relationship between
fluctuations and biological functions. The fluctuations discussed in this volume
are detected by the transient grating method, nuclear magnetic resonance, X-ray
diffraction and scattering, and computer simulation, among other methods. The
book presents various results of the studies of fluctuations in biological
processes that were obtained with these methods by the leading scientists in
their fields.
Zusammenfassung

Is the first book that discusses the importance of

fluctuations for biological reactions

Includes many illustrations of biological molecules

Deals with both experimental and computational approaches to
fluctuations

Inhaltsverzeichnis
Time-resolved detection of protein fluctuations during reactions.- Pressure perturbation: A prime tool to study conformational substates and volume fluctuations of biomolecular assemblies.- Watching a signaling protein function in real time via picosecond time-resolved Laue crystallography.- NMR explorations of biomolecular systems with rapid conformational exchanges.- Site-specific incorporation of fluorescent nonnatural amino acids in-to proteins and its application to fluorescence analysis of proteins.- Unfoldomes and unfoldomics: introducing intrinsically disordered proteins.- Structure, dynamics and function of staphylococcal nuclease.- Theory of molecular recognition and structural fluctuation of biomolecules.- Structural fluctuations of proteins in folding and ligand docking studied by replica-exchange simulations.- Spatio-temporal fluctuations of protein folding in living cells.- Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis.- Anti-tumor complexes formed by oleic acid and molten globule intermediates of proteins.
Details
Erscheinungsjahr: 2016
Fachbereich: Organische Chemie
Genre: Chemie
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: xii
270 S.
39 s/w Illustr.
73 farbige Illustr.
270 p. 112 illus.
73 illus. in color.
ISBN-13: 9784431558385
ISBN-10: 4431558381
Sprache: Englisch
Herstellernummer: 978-4-431-55838-5
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Terazima, Mazahide
Okamoto, Yuko
Ueoka, Ryuichi
Kataoka, Mikio
Herausgeber: Mazahide Terazima/Mikio Kataoka/Ryuichi Ueoka et al
Auflage: 1st ed. 2016
Hersteller: Springer Japan
Springer Tokyo
Maße: 241 x 160 x 20 mm
Von/Mit: Mazahide Terazima (u. a.)
Erscheinungsdatum: 19.02.2016
Gewicht: 0,646 kg
Artikel-ID: 104222963
Zusammenfassung

Is the first book that discusses the importance of

fluctuations for biological reactions

Includes many illustrations of biological molecules

Deals with both experimental and computational approaches to
fluctuations

Inhaltsverzeichnis
Time-resolved detection of protein fluctuations during reactions.- Pressure perturbation: A prime tool to study conformational substates and volume fluctuations of biomolecular assemblies.- Watching a signaling protein function in real time via picosecond time-resolved Laue crystallography.- NMR explorations of biomolecular systems with rapid conformational exchanges.- Site-specific incorporation of fluorescent nonnatural amino acids in-to proteins and its application to fluorescence analysis of proteins.- Unfoldomes and unfoldomics: introducing intrinsically disordered proteins.- Structure, dynamics and function of staphylococcal nuclease.- Theory of molecular recognition and structural fluctuation of biomolecules.- Structural fluctuations of proteins in folding and ligand docking studied by replica-exchange simulations.- Spatio-temporal fluctuations of protein folding in living cells.- Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis.- Anti-tumor complexes formed by oleic acid and molten globule intermediates of proteins.
Details
Erscheinungsjahr: 2016
Fachbereich: Organische Chemie
Genre: Chemie
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: xii
270 S.
39 s/w Illustr.
73 farbige Illustr.
270 p. 112 illus.
73 illus. in color.
ISBN-13: 9784431558385
ISBN-10: 4431558381
Sprache: Englisch
Herstellernummer: 978-4-431-55838-5
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Terazima, Mazahide
Okamoto, Yuko
Ueoka, Ryuichi
Kataoka, Mikio
Herausgeber: Mazahide Terazima/Mikio Kataoka/Ryuichi Ueoka et al
Auflage: 1st ed. 2016
Hersteller: Springer Japan
Springer Tokyo
Maße: 241 x 160 x 20 mm
Von/Mit: Mazahide Terazima (u. a.)
Erscheinungsdatum: 19.02.2016
Gewicht: 0,646 kg
Artikel-ID: 104222963
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