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Provides up-to-date and reliable information on the molecular basis of major hematologic diseases, authored and edited by leading experts in the field
Molecular techniques play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has improved our understanding of the pathogeneses of hematologic disorders and led to the development of exciting new drug therapies and recombinant proteins.
Molecular Hematology provides a core knowledgebase on the molecular basis of major hematologic diseases. Perfect for those with limited exposure to hematologic molecular biology, this accessible volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders such as hemophilia, anemia, multiple myeloma, thrombophilia, platelet disorders, leukemia, and lymphoma.
Now in its fifth edition, Molecular Hematology is fully revised to incorporate current hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, cancer cell biology, gene therapy and gene editing in clinical practice, and the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.
Including access to a companion Digital Edition providing interactive search, downloadable illustrations, and notation tools, Molecular Hematology, Fifth Edition, is an invaluable resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.
Provides up-to-date and reliable information on the molecular basis of major hematologic diseases, authored and edited by leading experts in the field
Molecular techniques play a central role in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has improved our understanding of the pathogeneses of hematologic disorders and led to the development of exciting new drug therapies and recombinant proteins.
Molecular Hematology provides a core knowledgebase on the molecular basis of major hematologic diseases. Perfect for those with limited exposure to hematologic molecular biology, this accessible volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders such as hemophilia, anemia, multiple myeloma, thrombophilia, platelet disorders, leukemia, and lymphoma.
Now in its fifth edition, Molecular Hematology is fully revised to incorporate current hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, cancer cell biology, gene therapy and gene editing in clinical practice, and the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.
Including access to a companion Digital Edition providing interactive search, downloadable illustrations, and notation tools, Molecular Hematology, Fifth Edition, is an invaluable resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.
DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.
List of contributors ix
Foreword xiii
Preface xv
1 Beginnings: the molecular pathology of hemoglobin 1
Douglas Higgs and Mohsin Badat
2 Stem cells 17
David T. Scadden
3 The genetics of acute myeloid leukemia 33
Amye M. Harrigan and Amy M. Trottier
4 Molecular diagnostics and risk assessment in myeloid malignancies 51
Christian Scharenberg and Torsten Haferlach
5 Molecular basis of acute lymphoblastic leukemia 67
Shunsuke Kimura and Charles G. Mullighan
6 Chronic myelogenous leukemia 83
Hagop Kantarjian, Elias Jabbour and Susan O'Brien
7 Myeloproliferative neoplasms 99
Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan
8 Lymphoma genetics 113
Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi
9 Molecular basis of chronic lymphocytic leukemia 127
Bita Fakhri and Alexey Danilov
10 The molecular biology of multiple myeloma 137
Udit Yadav and Wilson I. Gonsalves
11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145
Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris
12 Anemia of chronic disease 169
Tomas Ganz and Elizabeta Nemeth
13 Molecular basis of iron metabolism 175
Jodie L. Babitt and Tomas Ganz
14 Perspectives in genomics and sickle cell disease therapeutics 187
Ambroise Wonkam
15 Molecular coagulation and thrombophilia 201
Björn Dahlbäck and Andreas Hillarp
16 The molecular basis of hemophilia 217
Keith Gomez
17 The molecular basis of von Willebrand disease 231
Omid Seidizadeh and Luciano Baronciani
18 Platelet disorders 251
Kenneth J. Clemetson
19 The molecular basis of blood cell alloantigens 267
Winnie Chong, Louise Tilley and Colin Brown
20 Functions of blood group antigens 285
Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo
21 Autoimmune hematological disorders 299
Drew Provan and John W. Semple
22 Molecular therapeutics in hematology: gene therapy 321
William M. McKillop and Jeffrey A. Medin
23 Pharmacogenomics 343
Leo Kager and William E. Evans
24 Cancer stem cells 359
Sara Ali and Dominique Bonnet
25 CAR- T cell therapy 369
Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan
26 Molecular basis of transplantation 397
Pramila Krishnamurthy, Victoria Potter and Francesco Dazzi
Index 413
| Erscheinungsjahr: | 2024 |
|---|---|
| Fachbereich: | Allgemeine Lexika |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Inhalt: | 448 S. |
| ISBN-13: | 9781394180455 |
| ISBN-10: | 1394180454 |
| Sprache: | Englisch |
| Herstellernummer: | 1W394180450 |
| Einband: | Gebunden |
| Redaktion: |
Provan, Drew
Lazarus, Hillard M |
| Herausgeber: | Drew Provan/Hillard M Lazarus |
| Auflage: | 5th edition |
| Hersteller: | Wiley |
| Maße: | 279 x 221 x 30 mm |
| Von/Mit: | Drew Provan (u. a.) |
| Erscheinungsdatum: | 15.04.2024 |
| Gewicht: | 1,383 kg |
DREW PROVAN MD, FRCP, FRCPATH, Emeritus Reader in Autoimmune Hematology, Centre for Immunology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
HILLARD M. LAZARUS, MD, FACP, Professor of Hematology-Oncology, Full Professor of Medicine, The Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, Ohio 44106.
List of contributors ix
Foreword xiii
Preface xv
1 Beginnings: the molecular pathology of hemoglobin 1
Douglas Higgs and Mohsin Badat
2 Stem cells 17
David T. Scadden
3 The genetics of acute myeloid leukemia 33
Amye M. Harrigan and Amy M. Trottier
4 Molecular diagnostics and risk assessment in myeloid malignancies 51
Christian Scharenberg and Torsten Haferlach
5 Molecular basis of acute lymphoblastic leukemia 67
Shunsuke Kimura and Charles G. Mullighan
6 Chronic myelogenous leukemia 83
Hagop Kantarjian, Elias Jabbour and Susan O'Brien
7 Myeloproliferative neoplasms 99
Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan
8 Lymphoma genetics 113
Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi
9 Molecular basis of chronic lymphocytic leukemia 127
Bita Fakhri and Alexey Danilov
10 The molecular biology of multiple myeloma 137
Udit Yadav and Wilson I. Gonsalves
11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145
Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris
12 Anemia of chronic disease 169
Tomas Ganz and Elizabeta Nemeth
13 Molecular basis of iron metabolism 175
Jodie L. Babitt and Tomas Ganz
14 Perspectives in genomics and sickle cell disease therapeutics 187
Ambroise Wonkam
15 Molecular coagulation and thrombophilia 201
Björn Dahlbäck and Andreas Hillarp
16 The molecular basis of hemophilia 217
Keith Gomez
17 The molecular basis of von Willebrand disease 231
Omid Seidizadeh and Luciano Baronciani
18 Platelet disorders 251
Kenneth J. Clemetson
19 The molecular basis of blood cell alloantigens 267
Winnie Chong, Louise Tilley and Colin Brown
20 Functions of blood group antigens 285
Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo
21 Autoimmune hematological disorders 299
Drew Provan and John W. Semple
22 Molecular therapeutics in hematology: gene therapy 321
William M. McKillop and Jeffrey A. Medin
23 Pharmacogenomics 343
Leo Kager and William E. Evans
24 Cancer stem cells 359
Sara Ali and Dominique Bonnet
25 CAR- T cell therapy 369
Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan
26 Molecular basis of transplantation 397
Pramila Krishnamurthy, Victoria Potter and Francesco Dazzi
Index 413
| Erscheinungsjahr: | 2024 |
|---|---|
| Fachbereich: | Allgemeine Lexika |
| Genre: | Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Buch |
| Inhalt: | 448 S. |
| ISBN-13: | 9781394180455 |
| ISBN-10: | 1394180454 |
| Sprache: | Englisch |
| Herstellernummer: | 1W394180450 |
| Einband: | Gebunden |
| Redaktion: |
Provan, Drew
Lazarus, Hillard M |
| Herausgeber: | Drew Provan/Hillard M Lazarus |
| Auflage: | 5th edition |
| Hersteller: | Wiley |
| Maße: | 279 x 221 x 30 mm |
| Von/Mit: | Drew Provan (u. a.) |
| Erscheinungsdatum: | 15.04.2024 |
| Gewicht: | 1,383 kg |
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