Molecular, Cellular, and Metabolic Fundame...

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Beschreibung

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.

The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.

Über den Autor

Evandro Fei Fang is a molecular gerontologist and is currently Associate Professor at the Department of Clinical Molecular Biology, University of Oslo and the Akershus University Hospital, Norway. He has an extensive track record of mechanistic studies on human aging and mitophagy, and his main research interests currently center on exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan. He is currently pursuing the development of novel anti-ageing compounds using artificial intelligence combined with a cross-species wet-lab validation. Dr. Fang is also co-founder of the Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian anti-Alzheimer's disease (NO-AD) networks.

Inhaltsverzeichnis

1. Decoding the mystery of ageing and the hallmarks of ageing

Section I. The Genome 2. Epigenetic ageing and its reversal

Section II. Metabolism, Homeostasis and Communication 3. Nutrient sensing and aging 4. Dysregulated proteostasis

Section III. Autophagy and Bioenergetics 5. Autophagy and bioenergetics in aging

Section IV. Senescence 6. Senescence in Ageing

Section V. Applications 7. Ageing and the immune system 8. Canonical and novel strategies to delay or reverse ageing

Details

Erscheinungsjahr:	2022
Fachbereich:	Allgemeine Lexika
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
ISBN-13:	9780323916172
ISBN-10:	0323916171
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Fang, Evandro Fei Bergersen, Linda Hildegard Gilmour, Brian C.
Hersteller:	Elsevier Science
Maße:	12 x 152 x 229 mm
Von/Mit:	Evandro Fei Fang (u. a.)
Erscheinungsdatum:	26.10.2022
Gewicht:	0,39 kg

Artikel-ID: 120967279