Part I: Introduction: Metals, Metalloids, Redox Biology, and Neurodegeneration 1. Role of Metals and Metalloids in Redox Biology 2. Role of Metals in Neurodegeneration Part II: Pathology of Metal Toxicity 3. Pathological Manifestations and Mechanisms of Metal Toxicity 4. An Overview of Heavy Metal Research in Traditional Chinese Medicine Part III: Mechanisms of Restoring Metabolic Homeostasis 5. Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis 6. Gut Microbiome and Heavy Metals Part IV: Radionuclides Toxicity 7. A Review on Radionuclide Toxicity Part V: Benefits of Metals 8. Contribution of Bioavailable Silicon in Human Health 9. Benefits of Trivalent Chromium in Human Nutrition? 10. Trivalent Chromium: A Vital Insulin Sensitizer 11. Differential Impact of Organic Vanadium Compounds on Human Health: Deficiency States, Toxic Effects, and Potential Therapeutic Use 12. Vanadium-Speciation Chemistry Can Be Important When Assessing Health Effects on Living Systems Part VI: Toxic Manifestations by Diverse Heavy Metals and Metalloids 13. Clinical Toxicology of Copper: Source, Toxidrome, Mechanism of Toxicity and Management 14. Cadmium Exposure and Toxicity 15. Cobalt Toxicity and Human Health 16. Cobalt Toxicity 17. Iron-Siderophore and Tumorigenesis: Molecular Insight and Therapeutic Targets 18. Clinical Toxicology of Iron: Source, Toxidrome, Mechanism of Toxicity, and Management 19. Vanadium Toxicity Revisited: Striking the Right Balance between Potential New Generation Therapeutics and Adverse Side Effects 20. The Ubiquitous Lead-Biological Effects, Toxicity, and Management 21. Lead Toxicity: An Overview of Its Pathophysiology and Intervention Strategies 22. Arsenic Toxicity: Source, Mechanism, Global Health Complication, and Possible Way to Defeat 23. Clinical Toxicology of Mercury: Source, Toxidrome, Mechanism of Toxicity, and Management 24. An Overview of Tungsten Toxicity 25. Boron Toxicity: An Insight on Its Influence on Wheat Growth 26. Diversity of Mechanisms for Boron Toxicity in Mammals 27. Lithium: Is It Good or Bad for Plant Growth? 28. An Overview of Nickel Toxicity in Plants Commentary: A Treatise on Metal Toxicology