François Blachier worked as Research Director at the National Institute for Agriculture, Alimentation and Environment (INRAe). He was deputy director of the Nutrition Physiology and Alimentary Behavior laboratory, which is one of the research units belonging to the Université Paris-Saclay/AgroParisTech/INRAe consortium. After working as research assistant at McGill University in Montréal (Canada), at Brussels Free University (Belgium), and at the Institute of Animal Physiology and Genetics in Cambridge (UK), he received his PhD in Cellular and Molecular Pharmacology from Université Pierre and Marie Curie (Paris, France), and then joined INRAe. Presently, his main research interest is related to the metabolic crosstalk between the bacteria living in our gut and ourselves, and on the consequences of such bacterial metabolic activity towards dietary compounds on the intestinal metabolism and physiology in different situations including healthy state, and mucosal healing after an inflammatory episode. He has published over 170 articles (source PubMed) that have been cited over 9 000 times (Research Gate). He has worked as an expert for numerous international scientific organizations and received numerous invitations to give lectures in Europe, USA, Canada, China, Japan, Vietnam, Korea, Brazil, Chile, Egypt, and Togo. François Blachier worked as associate editor for the journals Amino Acids, and as member of the editorial board of the journals Microorganisms, Nutrition Research and Practice, Animal Nutrition and Journal of Animal Science and Biotechnology; and as academic editor for PLoS ONE.

Focusses on bacterial metabolites and their impact on host health and disease

Includes a comprehensive introduction on gut microbiota and interindividual variations

Provides answers by connecting research from nutrition, microbiology, toxicology and physiology

Chapter 1. Physiological and Metabolic Functions of the Intestinal Epithelium: From the Small to the Large Intestine.- Chapter 2. Intestine Offers Board and Lodging for Intestinal Microbes on a Short- or Long-Term Stay.- Chapter 3. Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine.- Chapter 4. Alimentation, Bacterial Metabolites, and Host Intestinal Epithelium.- Chapter 5. Modification of the Bacterial Metabolites by the Host after Absorption, and Consequences for the Peripheral Tissues' Metabolism, Physiology, and Pathophysiology.- Chapter 6. Lessons to Be Learned from Clinical and Experimental Research on the Intestinal Microbiota Metabolic Activity for Health Benefit and Perspectives.