Endothelium.- Atherosclerosis.- Imaging of atherosclerotic plaque and mechanisms of plaque rupture.- Current and Emerging Therapies in Atheroprotection.- Pathophysiology of angiogenesis and its role in vascular disease.- Vascular Biology of smooth muscle cells and restenosis, interventional strategies.- Vascular Arterial Haemodynamics.- Computerised fluid dynamics.- Physiological Haemostasis.- Hypercoagulable States.- Platelets in the Pathogenesis of Vascular Disease and their role as a therapeutic target .- Pathogenesis of Aortic Aneurysms.- Pathophysiology and management of genetic/ hereditary aortopathies.- Pathophysiology of Aortic dissection and connective tissue disorders.- Biomarkers in vascular disease.- Pathophysiology and principles of management of vasculitides.- Pathophysiology and principles of management of Raynaud's phenomenon.- SIRS, Sepsis and Multi-organ failure.- Pathophysiology of reperfusion injury.- Abdominal Compartment syndromes.- Limb Compartment Syndromes.- Pathophysiology of pain.- Post-amputation pain.- Treatment of neuropathic pain.- Principles of wound healing.- Pathophysiology and principles of varicose veins.- Pathophysiology and principles of management of the diabetic foot.- Lymphoedema - Principles, genetics and pathophysiology.- Graft materials past and future.- Pathophysiology of vascular graft infections.- Principles of radiation biology and radiation safety in vascular surgery.-Surgical Innovation and assessment of new technologies in Vascular Surgery.