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Section I

• CNS Demyelinating Disease (Cases 1-21)

• Case 1 A Woman With Subacute Painful Vision Loss

• Jiraporn Jitprapaikulsan, MD, M. Tariq Bhatti, MD, Eric R. Eggenberger, DO, and Marie D. Acierno, MD

• Case 2 Rapidly Progressive Numbness and Weakness After Soft-Tissue Abscess

• Elia Sechi, MD, and Dean M. Wingerchuk, MD

• Case 3 Weakness With Neck Flexion

• Brian G. Weinshenker, MD

• Case 4 New-Onset Right-Sided Numbness and Double Vision

• W. Oliver Tobin, MB, BCh, BAO, PhD

• Case 5 Progressive Left Lower Extremity Weakness and Thoracic Spinal Cord Lesion

• B. Mark Keegan, MD

• Case 6 Progressive Spasticity With a Single Magnetic Resonance Imaging Lesion

• Samantha A. Banks, MD, and Eoin P. Flanagan, MB, BCh

• Case 7 Fluctuating Vision Loss, Seizures, and Left Parieto-Occipital Mass

• Alicja Kalinowska-Lyszczarz, MD, PhD, W. Oliver Tobin, MB, BCh, BAO, PhD, Yong Guo, MD, PhD, and Claudia F. Lucchinetti, MD

• Case 8 Diffuse Pain and Abnormal Brain MRI Findings

• Andrew McKeon, MB, BCh, MD

• Case 9 Lesions Found by Chance

• Dean M. Wingerchuk, MD

• Case 10 Encephalopathy and Quadriparesis After an Upper Respiratory Tract Infection

• A. Sebastian Lopez Chiriboga, MD

• Case 11 Severe Monocular Vision Loss Followed by Gait Difficulty

• Brian G. Weinshenker, MD

• Case 12 Multiple Sclerosis and Cognitive Impairment

• Cristina Valencia-Sanchez, MD, PhD, and Jonathan L. Carter, MD

• Case 13 New-Onset Gait Difficulty With Kappa Free Light Chains in Cerebrospinal Fluid

• Maria Alice V. Willrich, PhD, and Ruba S. Saadeh

• Case 14 A Girl With Back Pain, Paresthesias, and Painful Vision Loss

• Cecilia Zivelonghi, MD, and Andrew McKeon, MB, BCh, MD

• Case 15 A Septuagenarian With Progressive Hemiparesis

• Roman Kassa, MD, and B. Mark Keegan, MD

• Case 16 Recurrent Demyelinating Episodes

• I. Vanessa Marin Collazo, MD

• Case 17 Breakthrough Disease While on Multiple Sclerosis Immunomodulatory Therapy

• Jonathan L. Carter, MD

• Case 18 Highly Active Multiple Sclerosis

• Roman Kassa, MD, and W. Oliver Tobin, MB, BCh, BAO, PhD

• Case 19 Progressive Gait Difficulties

• I. Vanessa Marin Collazo, MD

• Case 20 Progressive Cerebellar Ataxia After Natalizumab Treatment

• Michel Toledano, MD

• Case 21 Weakness and Dysarthria After Radiosurgery

• Andr