Forkel's biography is based not only on his own research but also on firsthand information provided by Bach's sons, Carl Philipp Emanuel and Wilhelm Friedemann, which gives the work a sense of authenticity and intimacy. The book traces Bach's early life in Eisenach, his musical education, and his career as a composer and performer in various German cities, culminating in his tenure as the Thomaskantor in Leipzig. Forkel highlights Bach's profound dedication to his craft and his ability to blend intricate musical techniques with deep emotional expression.

In addition to discussing Bach's life, Forkel delves into his music in a scholarly yet accessible manner, analyzing key works such as the Mass in B Minor, The Well-Tempered Clavier, and the Brandenburg Concertos. Forkel emphasizes Bach's mastery of counterpoint and his influence on the development of Western music, portraying him as a towering figure whose work transcended his time. Johann Sebastian Bach: His Life, Art, and Work remains a foundational text for Bach scholarship, offering a respectful and admiring portrayal of a composer whose influence on classical music is unparalleled.