David A. Bender was educated at North Ealing Primary School and Greenford County

Grammar School in London and then studied biochemistry at the University of Birmingham

in England from 1965 to 1968. He joined the Courtauld Institute of Biochemistry at the

Middlesex Hospital Medical School as a research assistant in 1968, was appointed as a

lecturer in biochemistry in 1970 and received his PhD (on the metabolism of aromatic

amino acids) from the University of London in 1971. The Middlesex Hospital Medical

School merged with University College London (UCL) in 1987, and he became a member

of the Department of Biochemistry and Molecular Biology at UCL. He was appointed as

senior lecturer in biochemistry in 1994 and professor of nutritional biochemistry in 2009.

He retired from UCL in 2011, with the title of Emeritus Professor. From 1994 until retirement,

he was the assistant faculty tutor to the medical students, and from 1998 he was

the subdean (Education) and director of studies for the early years of the medical course

at UCL.

His research interests have been in the fi eld of amino acid and vitamin nutritional

biochemistry, and he was a member of the working group on vitamins that formed part of

the expert committee that produced the 1991 report on Dietary Reference Values for Food

Energy and Nutrients for the United Kingdom, the European Union expert committee that

produced the 1993 report on Nutrient and Energy Intakes for the European Community

and the Food Safety Authority of Ireland working party on Safe Micronutrient Levels.

In addition to research publications, he has also written a number of books, including:

¿ Nutritional Biochemistry of the Vitamins , 2nd Edition, 2003, Cambridge University Press.

¿ Amino Acid Metabolism , 3rd Edition, 2012, Wiley- Blackwell.

¿ Benders' Dictionary of Nutrition and Food Technology , 8th Edition, 2006, Woodhead

Publishing, Oxford.

¿ Dictionary of Food and Nutrition , 3rd Edition, 2009, Oxford University Press.

For more information about David A. Bender, visit http:// david- [...].uk.

Shauna M. C. Cunningham was educated at Bank Street Primary School and Greenwood

Academy in Irvine, Scotland, before undertaking undergraduate studies at Glasgow

University. She moved to Aberdeen University in 1991 to study for a PhD. This was

followed by a period of postdoctoral research at Aberdeen University and Kurume

University Medical School, Japan, before she joined the Nutrition and Dietetics Teaching

Group in 2001 as a lecturer in nutritional physiology and biochemistry at Robert Gordon

University in Aberdeen. Shauna continues to teach student nutritionists and dietitians at

Robert Gordon University, with a particular interest in metabolism and its relationship

with diet.

Contents

Preface .......................................................................................................................................... xvii

Authors .......................................................................................................................................... xix

Additional Resources on the Website: Metabolism Online - The Virtual Tutorial ........................ xxi

Chapter 1 Why Eat? ..................................................................................................................... 1

Chapter 2 Enzymes and Metabolic Pathways ...................................................................... 21

Chapter 3 The Role of ATP in Metabolism .......................................................................... 53

Chapter 4 Digestion and Absorption .................................................................................... 83

Chapter 5 Energy Nutrition: The Metabolism of Carbohydrates and Fats .................. 121

Chapter 6 Diet and Health: Nutrition and Chronic Noncommunicable Diseases .... 1 73

Chapter 7 Overweight and Obesity ..................................................................................... 223

Chapter 8 Protein- Energy Malnutrition: Problems of Undernutrition ......................... 247

Chapter 9 Protein Nutrition and Metabolism ................................................................... 259

Chapter 10 The Integration and Control of Metabolism ................................................... 293

Chapter 11 Micronutrients: The Vitamins and Minerals .................................................. 323

Index ............................................................................................................................................. 421