Inflammation-Associated Depression: Eviden...

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Sprache: Englisch

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Beschreibung

Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book Inflammation-Associated Depression is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Zusammenfassung

Reviews exhaustively the key recent research into the relationship between inflammation and depression

Covers the preclinical aspects of this research and its clinical implications

Broadens our understanding of the role of inflammation in health and disease

Inhaltsverzeichnis

Section 1: Evidence for inflammation-associated depression.- Evidence for inflammation-associated depression.- Role of inflammation in the development of neuropsychiatric symptom domains.- Inflammation-associated comorbidity.- Section 2: Mechanisms of inflammation-associated depression.- Mechanisms of inflammation-associated depression Immune-to-brain communication pathways and cytokines.- Immune-to-brain communication pathways.- Mechanisms of inflammation-associated depression.- Role of the kynurenine metabolism pathway.- Depression in autoimmune diseases.- Stress-induced microglia activation.- Inflammation effects on brain glutamate.- The role of dopamine.- Brain structures implicated in inflammation-associated depression.- Role of kynurenine metabolism pathway.- Suicidality. Section 3: Clinical implications of inflammation-associated depression.- The promise and limitations of anti-inflammatory agents.- Are non-steroidal anti-inflammatory drugs.- Does diet matter?- Role of neuroimunological factors.

Erscheinungsjahr:	2018
Fachbereich:	Therapie
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Reihe:	Current Topics in Behavioral Neurosciences
Inhalt:	x 356 S. 10 s/w Illustr. 20 farbige Illustr. 356 p. 30 illus. 20 illus. in color.
ISBN-13:	9783319845814
ISBN-10:	3319845810
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Dantzer, Robert Capuron, Lucile
Redaktion:	Dantzer, Robert Capuron, Lucile
Herausgeber:	Robert Dantzer/Lucile Capuron
Auflage:	Softcover reprint of the original 1st edition 2017
Hersteller:	Springer Springer International Publishing AG Current Topics in Behavioral Neurosciences
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 20 mm
Von/Mit:	Robert Dantzer (u. a.)
Erscheinungsdatum:	07.07.2018
Gewicht:	0,557 kg