This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis.
The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.
This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis.
The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.
Über den Autor
> 350 research papers and 2 books.
Zusammenfassung
Includes conventional and NGS technologies for microbiome analysis
Throws light on the correlation between microbiomes and diseased eye
Bridges the knowledge gap between microbiology, molecular microbiology and clinical microbiology
Inhaltsverzeichnis
Chapter 1. Introduction: From the gut microbiome to the ocular surface microbiome: are they associated?.- Chapter 2. The cultivable bacteria of the human eye.- Chapter 3. The microbiome of the human eye.- Chapter 4. Antimicrobial resistance in ocular bacteria .- Chapter 5. The cultivable fungi of the human eye.- Chapter 6. The Mycobiome of the human eye.- Chapter 7. Viruses of the human eye.- Chapter 8. Virome of the healthy human eye.- Chapter 9. Virome of the diseased human eye.- Chapter 10. Cellular and molecular basis of ocular diseases.- Chapter 11. What we need to know about the human ocular microbiome.
