A. VICTOR HOFFBRAND, Emeritus Professor of Haematology, University College London, UK.

CONTRIBUTING AUTHORS

PRATIMA CHOWDARY, Professor of Haemophillia and Haemostasis, University College London; Consultant Haematologist, KD Haemophilia and Thrombosis Centre, Royal Free Hospital, London.

GRAHAM COLLINS, Associate Professor of Haematology and Consultant Haematologist, Oxford Cancer and Haematology Centre, Oxford, UK.

JUSTIN LOKE, AACR-CRUK Transatlantic Fellow, Dana-Farber Cancer Institute, Boston, USA and University of Birmingham, Birmingham, UK.

Preface to the Ninth Edition iv

About the Companion Website v

1 Haemopoiesis 1

2 Erythropoiesis and general aspects of anaemia 11

3 Hypochromic anaemias 27

4 Iron overload 42

5 Megaloblastic anaemias and other macrocytic anaemias 50

6 Haemolytic anaemias 65

7 Genetic disorders of haemoglobin 79

8 The white cells, part 1: granulocytes, monocytes and their benign disorders 99

9 The white cells, part 2: lymphocytes and their benign disorders 116

10 The spleen 131

11 The aetiology and genetics of haematological neoplasia 138

12 Management of haematological malignancy 155

13 Acute myeloid leukaemia 168

14 Chronic myeloid leukaemia 185

15 Myeloproliferative neoplasms 194

16 Myelodysplastic neoplasms 210

17 Acute lymphoblastic leukaemia 222

18 The chronic lymphocytic leukaemias 236

19 Hodgkin lymphoma 246

20 Non-Hodgkin lymphomas 1: General aspects 259

21 Non-Hodgkin lymphomas 2: Individual diseases 270

22 Multiple myeloma and related plasma cell neoplasms 287

23 Amyloid 302

24 Aplastic anaemia and bone marrow failure syndromes 309

25 Haemopoietic stem cell transplantation 320

26 Platelets, coagulation and normal haemostasis 337

27 Bleeding disorders caused by platelet and vascular abnormalities 355

28 Hereditary coagulation disorders 370

29 Acquired coagulation disorders and thrombotic microangiopathies 385

30 Thrombosis 1: Pathogenesis and diagnosis 399

31 Thrombosis 2: Treatment 417

32 Haematological changes in systemic diseases 437

33 Blood transfusion 451

34 Pregnancy and neonatal haematology 465

Appendix: 5th edition (2022) of the World Health Organization Classification of Haematolymphoid Tumours 475

Index 478