Histiocytic Neoplasms and Related Disorders

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Sprache: Englisch

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Beschreibung

This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.

Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Über den Autor

Oussama Abla, MD

Chair, Rare Histiocytoses Steering Committee- Histiocyte Society, Associate Professor of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario,

Canada

Gritta Janka, MD, PhD

Chair, HLH Steering Committee, Histiocyte Society, Professor emeritus of Pediatrics, University Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany

Zusammenfassung

First comprehensive book on histiocytic disorders in over ten years

Features the most recent advances and treatment strategies for common and uncommon histiocytic disorders

Written by international experts in the field

Inhaltsverzeichnis

Pathology of Histiocytic Disorders and Neoplasms and Related Disorders.- Biology and Genomics of LCH and Related Disorders.- Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children.- Central Nervous System Langerhans Cell Histiocytosis.- First-line Treatment of Pediatric Langerhans Cell Histiocytosis.- Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children.- Adult Langerhans Cell Histiocytosis.- Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy.- Classification, Clinical Manifestations and Diagnostics of HLH.- CNS involvement in HLH (CNS-HLH).- Genetics and Pathogenesis of Haemophagocytic Lymphohistiocytosis.- Hemophagocytic Lymphohistiocytosis Associated with Malignancies and with Epstein Barr Virus.- Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH).- Treatment of Newly Diagnosed HLH and Refractory Disease.- Hematopoietic Cell Transplantation and Novel Therapies in HemophagocyticLymphohistiocytosis.- HLH in Adults.- Juvenile Xanthogranuloma and Related Non-LCH Disorders.- Erdheim-Chester Disease.- Rosai-Dorfman Disease.- Malignant Histiocytoses.

Details

Erscheinungsjahr:	2017
Fachbereich:	Andere Fachgebiete
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	xii 392 S. 22 s/w Illustr. 74 farbige Illustr. 392 p. 96 illus. 74 illus. in color.
ISBN-13:	9783319596310
ISBN-10:	3319596314
Sprache:	Englisch
Herstellernummer:	978-3-319-59631-0
Einband:	Gebunden
Redaktion:	Abla, Oussama Janka, Gritta
Herausgeber:	Oussama Abla/Gritta Janka
Hersteller:	Springer-Verlag GmbH Springer International Publishing AG
Abbildungen:	23 schwarz-weiße und 72 farbige Abbildungen, 50 schwarz-weiße Tabellen, Bibliographie
Maße:	260 x 183 x 26 mm
Von/Mit:	Oussama Abla (u. a.)
Erscheinungsdatum:	23.12.2017
Gewicht:	1,053 kg

Artikel-ID: 110759857