Salvatore Maurizio Maggiore has been a Full Professor of Anaesthesiology and Critical Care Medicine at the "Gabriele d'Annunzio" University of Chieti-Pescara, Italy, and Chief of the general ICU at the SS. Annunziata Hospital of Chieti, Italy since 2018. He graduated in Anaesthesiology and Intensive Care Medicine from the University of Bari, Italy in 1998, undertook a clinical and research fellowship in the medical ICU of the Henri Mondor hospital, Paris XII University, and worked as a senior physician and Assistant Professor at the A. Gemelli hospital, Catholic University of Rome, Italy, before being appointed as Associate Professor of Anaesthesiology and Critical Care Medicine at the "Gabriele d'Annunzio" University of Chieti-Pescara, Italy. He is currentlyin charge of the Residency Program for Anaesthesiology and Critical Care Medicine and teaches on acute respiratory failure, respiratory pathophysiology, and mechanical ventilation in several other Residency Programs and in the Medical Degree at the G. d'Annunzio University of Chieti-Pescara, Italy, and in other Master Degree courses at other Italian Universities (Bologna, Milan). His main research interests are focused on acute respiratory failure, respiratory mechanics, invasive and non-invasive ventilatory support, cardiovascular effects of mechanical ventilation, and ethics in intensive care. He is the author of over 100 peer-reviewed papers, reviews, editorials and book chapters, and wrote several articles on the application of High-Flow Nasal Cannula in critically ill patients. He has received several awards and grants from the Italian Society of Intensive Care, the European Respiratory Society, and the American Thoracic Society, and is regularly invited to speak at the main national and international congresses in Pulmonology and Intensive Care Medicine. He is a member of several Scientific Societies (SIAARTI, ESA, ESICM). He was a Deputy Editor of the journal "Intensive Care Medicine" (2007-2013) and the former Chair of the Editorial and Publishing Committee and a former member of the Executive Committee of the European Society of Intensive Care Medicine (ESICM) (2011-2014).

Depicts both the mechanisms of action as well as the physiological effects of high-flow nasal cannula (HFNC)

Provides the reader with in-depth information on the technical features and different devices available for oxygen-therapy based on high-flow nasal cannula (HFNC)

Provides a broad overview of current and future applications of HFNC in acute as well as chronic settings - including pediatric applications

1 Conventional oxygen therapy: technical and physiologic issues.- 2 High-flow: technical aspect.- 3 Physiological effects of high flow.- 4 Clinical applications of high flow nasal cannula in hypoxemic acute respiratory failure.- 5 Clinical applications of high flow nasal cannula during intubation and weaning from mechanical ventilation.- 6 Clinical applications of high flow nasal cannula in the operating room.- 7 Clinical applications in the acute setting: obstructive lung diseases.- 8 Clinical applications in Pulmonary rehabilitation.- 9 Clinical applications in particular setting.- 10 Physiological Effects and clinical applications in children.- 11 Future perspectives.