Marc Semigran

is Associate Professor of Medicine, Harvard Medical School; Director, Heart Failure and Transplant Service, Massachusetts General Hospital; Attending Physician, Cardiac Catheterization, Laboratory, Medical Services, Coronary Care Unit, and Cardiology Consultation Service, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of fellow of several organizations, including the American College of Physicians, the American College of Cardiology, the American Heart Association, the International Society of Heart and Lung Transplantation, and the Working Group of Transplant Cardiologists.



Dr. Semigran is a reviewer for several publications, including the American Journal of Cardiology, Anesthesia, Journal of the American College of Cardiology, New England Journal of Medicine, Journal of the American College of Cardiology, Arthritis and Rheumatism, Circulation, and the Journal of Heart and Lung Transplantation. He also contributed to the first edition of Heart Failure.

Jordan T. Shin

is Professor of Medicine, Harvard Medical School and Assistant Physician, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of numerous organizations, including the Massachusetts Medical Society, the American Medical Association, American College of Cardiology, the American Association for the Advancement of Science, Member, the American Heart Association, and the Heart Failure Society of America.

Part 1: Cellular and Molecular Basis for Heart Failure A Brief Primer on the Development of the Heart
Serge Gregoire and Sean WuThe Genetics of Dilated and Hypertrophic Cardiomyopathies
Calum MacraeMolecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
Gerald W Dorn II MDExcitation-Contraction Coupling in the Normal and Failing Heart
Mattew Coggins, Bernhard Haring, Federica del Monte Myocardial energetics and cellular metabolism in the failing heart
Joanne S. Ingwall Animal Models of Heart Failure
William Carlson
Part II: Pathophysiology of Heart Failure Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
Kibar Yared, Judy Hung Neurohormonal and Cytokine Activation in Heart Failure
Dennis McNamaraCardiomyopathies in the Adult
Richard RodehefferWater and Salt: the cardiorenal syndrome
Maria Rosa Costanzo
Part III: The Demographics, Diagnosis and Monitoring of Heart Failure: The Clinical Syndrome of Heart Failure
Thomas DiSalvo, Jordon ShinClinical Profiles and Bedside Assessment
Lynne Warner Stevenson Prognosis in Heart Failure
J. Susie Woo, Wayne C. Levy,
Biomarkers in Heart Failure
Ravi V. Shah, MD and Thomas J. WangNoninvasive Imaging Modalities for the Evaluation of Heart Failure
Kimberly A. Parks and Malissa J. WoodRole of Invasive Monitoring in Heart Failure: Pulmonary Artery Catheters in the Post-ESCAPE Era
W. H. Wilson Tang, Gary S. Francis
Part IV: The Medical Treatment of Clinical Heart Failure Conventional Therapy of Chronic Heart Failure: Diuretics, Vasodilators, and Digoxin
G. William Dec, MDConventional Therapy of Chronic Heart