Classification of the schizophrenia spectrum disorders - Neurobiological challenges - Phenotypic and endophenotypic presentations - Therapeutic approaches - Outcomes

Foreword. Schizophrenia Spectrum Disorders: Insights from views across 100 years.- 1. The schizophrenia construct after 100 years of challenges.- 2. Diagnosis and classification of the schizophrenia spectrum disorders.- 3. Toward Multidimensional Continuum Model of functional psychoses for research purposes.- 4. Irving Gottesman and the schizophrenia spectrum.- 5. Schizotypy: Reflections on the bridge to schizophrenia and obstacles on the road ahead to etiology and pathogenesis.- 6. Autism spectrum disorders and schizophrenia.- 7. One hundred years of insanity: genomic, psychological, and evolutionary models of autism in relation to schizophrenia.- 8. Quantifying the dynamics of central systemic degeneration in schizophrenia.- 9. Schizophrenia runs in some families, but where are the genes?- 10. Changes in gene expression in subjects with schizophrenia associated with disease progression.- 11. Amino acids in schizophrenia -- glycine, serine and arginine.- 12. Developmental consequences of prenatal immune activation.- 13. Glutamatergic neurotransmission abnormalities and schizophrenia.- 14. Mathematical models in schizophrenia.- 15. Methamphetamine psychosis: a model for biomarker discovery in schizophrenia.- 16. What does proteomics tell us about schizophrenia?- 17. The role of 3¿-hydroxy-5¿-pregnan-20-one in mediating the development and/or expression of schizophrenia spectrum disorders: Findings in rodents models and clinical populations.- 18. Neural substrates of emotion dysfunctions in patients with schizophrenia spectrum disorders.- 19. Brain morphological abnormalities at the onset of schizophrenia and other psychotic disorders. A review of the evidence.- 20. Mapping prodromal psychosis.- Afterword. The future of the schizophrenia construct and acquisition of new knowledge.