Mahima Bajpayee: Genotoxicity Assessment

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Cover: 9781493996483 | Genotoxicity Assessment | Methods and Protocols | Bajpayee (u. a.)

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Sprache: Englisch

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Beschreibung

This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls.

Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.

Zusammenfassung

Includes cutting-edge techniques

Provides step-by-step detail essential for reproducible results

Contains key implementation advice from the experts

Inhaltsverzeichnis

In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.- Erythrocyte-Based Pig-a Gene Mutation Assay.- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes.- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests.- Dicentric Chromosome Assay (DCA) and Cytokinesis-Block Micronucleus (CBMN) Assay in the Field of Biological Dosimetry.- Chromosomal Aberration Test in Human Lymphocytes.- In Vivo Micronucleus Assay in Mouse Bone Marrow.- Micronucleus Cytome Assays in Human Lymphocytes and Buccal Cells.- Micronucleus Analysis by Flow Cytometry.- Hen's Egg Test for Micronucleus Induction (HET-MN).- Comparative Genomic Hybridization (CGH) in Genotoxicology.- The Comet Assay: Assessment of In Vitroand In Vivo DNA Damage.- The Comet Assay in Human Biomonitoring.- The Comet Assay in Marine Animals.- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers.- Detection of DNA Double Strand Breaks Using Pulse Field Gel Electrophoresis.- Detection of UV-Induced Thymine Dimers.- Micronucleus Assay with Tetrad Cells of Tradescantia.- The Wing-Spot and the Comet Tests as Useful Assays for Detecting Genotoxicity in Drosophila.- In Silico Approaches in Predictive Genetic Toxicology.

Details

Erscheinungsjahr:	2020
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Seiten:	392
Reihe:	Methods in Molecular Biology
Inhalt:	xi 378 S. 37 s/w Illustr. 57 farbige Illustr. 378 p. 94 illus. 57 illus. in color.
ISBN-13:	9781493996483
ISBN-10:	1493996487
Sprache:	Englisch
Ausstattung / Beilage:	Paperback
Einband:	Kartoniert / Broschiert
Redaktion:	Bajpayee, Mahima Dhawan, Alok
Herausgeber:	Alok Dhawan/Mahima Bajpayee
Auflage:	2nd ed. 2019
Hersteller:	Springer US Springer New York Methods in Molecular Biology
Maße:	254 x 178 x 22 mm
Von/Mit:	Mahima Bajpayee (u. a.)
Erscheinungsdatum:	02.09.2020
Gewicht:	0,735 kg