Genome Mapping and Genomics in Human and N...

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Beschreibung

This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.
Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architectureof normal and disease-related complex phenotypes using data from both humans and non-human primates.

Zusammenfassung

Will be of interest to scientists in the fields of genetics, evolutionary biology, bioinformatics, genetic epidemiology, pharmacogenetics, anthropology and biomedical research

Reviews the key genetic sequencing and mapping techniques

An invaluable work that will promote further genomic research

Includes supplementary material: [...]

Inhaltsverzeichnis

The Utility of Genomics for Studying Primate Biology.- The Human Genome Project: Where Are We Now and Where Are We Going?.- Linkage Mapping: Localizing the Genes that Shape Human Variation.- Association Studies to Map Genes for Disease-Related Traits in Humans.- Gene Expression Studies and Complex Diseases.- Copy Number Variations and Chronic Diseases.- Applications of Genomic Methods to Studies of Wild Primate Populations.- Comparative Genomics: Tools for Study of Complex Diseases.- Genetic Structure and Its Implications for Genetic Epidemiology: Aleutian Island Populations.- Mapping Genes in Isolated Populations: Lessons from the Old Order Amish.- Genetics of Cardiovascular Disease in Minority Populations.- Mapping of Susceptibility Genes for Obesity, Type 2 Diabetes, and the Metabolic Syndrome in Human Populations.- Genetic Influence on the Human Brain.- Variation, Genetics, and Evolution of the Primate Craniofacial Complex.- Genetic Influences on Behavior in Nonhuman Primates.-Genomic Studies of Human Populations: Re-sequencing Approaches to the Identification of Human Quantitative Loci.

Details

Erscheinungsjahr:	2015
Fachbereich:	Zoologie
Genre:	Biologie , Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Buch
Inhalt:	viii 305 S. 29 s/w Illustr. 10 farbige Illustr. 305 p. 39 illus. 10 illus. in color.
ISBN-13:	9783662463055
ISBN-10:	3662463059
Sprache:	Englisch
Herstellernummer:	978-3-662-46305-5
Einband:	Gebunden
Redaktion:	Duggirala, Ravindranath Almasy, Laura Kole, Chittaranjan Paul, Solomon F. D. Williams-Blangero, Sarah
Herausgeber:	Ravindranath Duggirala/Laura Almasy/Sarah Williams-Blangero et al
Hersteller:	Springer Berlin Springer Berlin Heidelberg
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	260 x 183 x 23 mm
Von/Mit:	Ravindranath Duggirala (u. a.)
Erscheinungsdatum:	22.04.2015
Gewicht:	0,794 kg

Artikel-ID: 104915129