Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis.
Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).

VOLUME I Part 1: Structure and Function of Bone, Joints, and Connective Tissue 1. Biology of the Normal Joint, 1
Carla R. Scanzello and Steven R. Goldring 2. Synovium, 20
Douglas J. Veale and Gary S. Firestein 3. Cartilage and Chondrocytes, 34
Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser 4. Biology, Physiology, and Morphology of Bone, 60
Aline Bozec, Anika Grüneboom, and Georg Schett 5. Muscle: Anatomy, Physiology, and Biochemistry, 67
Mark S. Miller, Edward P. Debold, and Michael J. Toth 6. Biomechanics, 80
Kenton R. Kaufman and KaiNan An 7. Regenerative Medicine and Tissue Engineering, 92Frank P. Luyten, Cosimo De Bari, and Francesco Dell'Accio 8. Proteinases and Matrix Degradation, 109
Yoshifumi Itoh Part 2: Cells Involved in Autoimmune Diseases and Inflammation 9. Dendritic Cells, 132
Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj 10. Mononuclear Phagocytes, 149
Deborah R. Winter, Anna Montgomery, and Harris Perlman 11. Neutrophils, 161Binita Shah, Nathalie Burg, and Michael H. Pillinger 12. T Lymphocytes, 182Ralph C. Budd 13. B Cells, 199Yong-Rui Zou, Christine Grimaldi, and Betty Diamond 14. Fibroblasts and Fibroblast-like Synoviocytes, 222Christopher D. Buckley and Andrew Filer 15. Mast Cells, 241
Peter A. Nigrovic 16. Innate Lymphoid Cells and Natural Killer Cells, 254Michael A. Paley and Wayne M. Yokoyama 17. Platelets and Megakaryocytes, 262Eric Boilard and Peter A. Nigrovic Part 3: Effector Mechanisms in Autoimmunity and Inflammation 18. Principles of Signaling, 273
Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos 19. The Immunologic Repercussions of Cell Death, 286
Helen M. Beere and Douglas R. Green 20. Innate Immunity, 306Gregoire Lauvau and Steven A. Porcelli 21. Adaptive Immunity, 320Martha S. Jordan and Gary A. Koretzky 22. Autoimmunity and Tolerance, 337Dwight H. Kono and Argyrios N. Theofilopoulos 23. The Microbiome in Health and Disease, 355
Rob Knight 24. Metabolic Regulation of Immunity, 368
Ruoning Wang, Tingting Wang, and Stephen Tait 25. Genetics of Rheumatic Diseases, 378Stephen Eyre and Anne Barton 26. Epigenetics of Rheumatic Diseases, 393Amr H. Sawalha and Matlock A. Jeffries 27. Complement System, 409
V. Michael Holers and Leendert A. Trouw 28. Prostaglandins, Leukotrienes, and Related Compounds, 420
Robert B. Zurier 29. Chemokines and Cellular Recruitment, 437Gerard Graham 30. Angiogenesis, 445Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale 31. Cytokines, 455
Iain B. McInnes 32. Experimental Models for Rheumatoid Arthritis, 467
Rikard Holmdahl 33. Neuronal Regulation of Pain and Inflammation, 480
Camilla I. Svensson and Linda S. Sorkin Part 4: Broad Issues in the Approach to Rheumatic Disease 34. Clinical Research Methods in Rheumatic Disease, 495
Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag 35. Economic Impact of Arthritis and Rheumatic Conditions, 510Louise B. Murphy 36. Assessment of Health Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell 37. Biomarkers in Rheumatology, 536 Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan 38. Occupational and Recreational Musculoskeletal Disorders, 551Richard S. Panush 39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb 40. Cancer Risk in Rheumatic Diseases, 579
Eric L. Matteson 41. Introduction to Physical Medicine and Rehabilitation, 592
Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke 42. Pregnancy and Rheumatic Diseases, 604Lisa R. Sammaritano and Bonnie L. Bermas Part 5: Evaluation of Generalized and Localized Symptoms 43. History and Physical Examination of the Musculoskeletal System, 621John M. Davis III, Kevin G. Moder, and Gene G. Hunder 44. Ultrasound in Rheumatology, 638Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella 45. Evaluation of Monoarticular and Polyarticular Arthritis, 663Ronald F. van Vollenhoven 46. Skin and Rheumatic Diseases, 678David F. Fiorentino and Victoria P. Werth 47. The Eye and Rheumatic Diseases, 702James T. Rosenbaum Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain 48. Neck Pain, 711Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng 49. Shoulder Pain, 727Scott David Martin and Thomas S. Thornhill 50. Low Back Pain, 753Rajiv Dixit 51. Hip and Knee Pain, 776 James I. Huddleston, III, and Stuart Goodman 52. Foot and Ankle Pain, 792 Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan 53. Hand and Wrist Pain, 800Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart 54. Temporomandibular Joint Pain, 813Daniel M. Laskin 55. Fibromyalgia, 825Leslie J. Crofford Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases 56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841Hani S. El-Gabalawy and Stacy Tanner 57. Arthrocentesis and Injection of Joints and Soft Tissues, 859Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield 58. Anti-nuclear Antibodies, 875Stanford L. Peng and Joseph E. Craft 59. Autoantibodies in Rheumatoid Arthritis, 890Erika Darrah, Antony Rosen, and Felipe Andrade 60. Acute Phase Reactants, 907Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena 61.Imaging in Rheumatic Diseases, 920 Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert Part 8: Pharmacology of Anti-rheumatic Drugs 62. Therapeutic Targeting of Prostanoids, 965Leslie J. Crofford 63. Glucocorticoid Therapy, 985Marlies C. van der Goes and Johannes W.G. Jacobs 64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007Amy C. Cannella and James R. O'Dell 65. Immunosuppressive Drugs, 1031Jacob M. van Laar 66. Anti-cytokine Therapies, 1046 Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin 67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068Peter C. Taylor 68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091Virginia Reddy and Stanley Cohen 69. Urate-Lowering Therapy, 1111Ted R. Mikuls 70. Bisphosphonates, 1125Arthur C. Santora II and Kenneth G. Saag 71. Analgesic Agents in Rheumatic Disease, 1135Gregory R. Polston and Mark S. Wallace 72. Nutrition and Rheumatic Diseases, 1156Lisa K. Stamp and Leslie G. Cleland 73. Evaluation and Management of Early Undifferentiated Arthritis, 1173Karim Raza VOLUME II Part 9: Rheumatoid Arthritis 74. Etiology of Rheumatoid Arthritis, 1181Gary S. Firestein 75. Pathogenesis of Rheumatoid Arthritis, 1200Gary S. Firestein 76. Clinical Features of Rheumatoid Arthritis, 1236Bryant R. England and Ted R. Mikuls 77. Treatment of Rheumatoid Arthritis, 1258James R. O'Dell 78. Sjögren's Syndrome, 1284E. William St. Clair and David L. Leverenz Part 10: Spondyloarthritis 79. Etiology and Pathogenesis of Spondyloarthritis, 1307Keith A. Sikora and Robert A. Colbert 80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis, 1319Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor 81. Reactive Arthritis, 1344John D. Carter and Alan P. Hudson 82. Psoriatic Arthritis, 1359Oliver FitzGerald and Conor Magee 83. Inflammatory Bowel Disease-Associated Arthritis and Other Enteropathic Arthropathies, 1381Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie Part 11: Systemic Lupus Erythematosus and Related Syndromes 84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396Mary K. Crow 85. Clinical Features of Systemic Lupus Erythematosus, 1413Maria Dall'Era and David Wofsy 86. Treatment of Systemic Lupus Erythematosus, 1437Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas 87. Antiphospholipid Syndrome, 1460Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes 88. Etiology and Pathogenesis of Systemic Sclerosis, 1473John Varga 89. Clinical Features and Treatment of Scleroderma, 1499Fredrick M. Wigley and Francesco Boin 90. Inflammatory Diseases of Muscle and Other Myopathies, 1539Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg 91. Overlap Syndromes, 1569Jonathan Graf Part 13: Vasculitis 92. Classification and Epidemiology of Systemic Vasculitis, 1584Rennie L. Rhee and Peter A. Merkel 93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu's Arteritis, 1595David B. Hellmann 94. Anti-neutrophil Cytoplasmic Antibody- Associated Vasculitis, 1617Sharon A. Chung and Paul A. Monach 95. Polyarteritis Nodosa and Related Disorders, 1634Raashid Luqmani and Abid Awisat 96. Immune Complex-Mediated Small Vessel Vasculitis, 1649John H. Stone 97. Primary Angiitis of the Central Nervous System, 1659Rula A. Hajj-Ali and Carol A. Langford 98. Behçet's Disease, 1666Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation 99. Pathogenesis of Inflammasome-Mediated Diseases, 1676Hal M. Hoffman and Lori Broderick 100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687Robert T. Keenan, Michael Toprover, and Michael H. Pillinger 101. Clinical Features and Treatment of Gout, 1710Nicola Dalbeth 102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732 Robert Terkeltaub 103. Familial Autoinflammatory Syndromes, 1752Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders 104. Pathogenesis of Osteoarthritis, 1770Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels 105. Clinical Features of Osteoarthritis, 1789Amanda E. Nelson 106. Treatment of Osteoarthritis, 1803Devyani Misra, Deepak Kumar, and Tuhina Neogi 107. Metabolic Bone Disease, 1819Nancy E. Lane 108. Proliferative Bone Diseases, 1839Reuven Mader 109. Osteonecrosis, 1852Christopher Chang, Adam...