Jixian Wang: Exposure-Response Modeling

Cover: 9780367738044 | Exposure-Response Modeling | Methods and Practical Implementation

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Sprache: Englisch

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Beschreibung

This book explores a wide range of topics in exposure-response modeling, from traditional PKPD modeling to other areas in drug development and beyond. It incorporates numerous examples and software programs for implementing novel methods. The book emphasizes dose adjustment and treatment adaptation based on dynamic exposure-response models, illu

Über den Autor

Jixian Wang is a principal statistician at Celgene International, Switzerland. He worked on drug development for 14 years at GSK and Novartis Pharma and was an academic researcher at Edinburgh University and Dundee University, where he is still an honorary research fellow. His research interests include statistical methodology and its applications to real problems in pharmaceuticals, including exposure-safety, PKPD modeling, treatment/dose selection, health economics, benefit-risk and health technology assessments, and optimal trial design.

Inhaltsverzeichnis

Introduction. Basic exposure and exposure-response models. Dose-exposure and exposure-response models for longitudinal data. Sequential and simultaneous exposure-response modeling. Exposure-risk modeling for time-to-event data. Modeling dynamic exposure-response relationships. Bayesian modeling and model-based decision analysis. Confounding bias and causal inference in exposure-response modeling. Dose-response relationship, dose determination, and adjustment. Implementation using software. Appendix. Bibliography. Index.

Erscheinungsjahr:	2020
Fachbereich:	Wahrscheinlichkeitstheorie
Genre:	Importe , Mathematik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
ISBN-13:	9780367738044
ISBN-10:	036773804X
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Wang, Jixian
Hersteller:	CRC Press
Verantwortliche Person für die EU:	Libri GmbH, Europaallee 1, D-36244 Bad Hersfeld, gpsr@libri.de
Maße:	231 x 155 x 25 mm
Von/Mit:	Jixian Wang
Erscheinungsdatum:	18.12.2020
Gewicht:	0,54 kg