Exploring and Exploiting Genetic Risk for ...

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Beschreibung

"This volume examines the state of psychiatric genetics and charts a path forward for further discovery and translation"-- Provided by publisher.

Über den Autor

edited Joshua A. Gordon and Elisabeth B. Binder

Inhaltsverzeichnis

List of Contributors vii
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325

Details

Erscheinungsjahr:	2023
Fachbereich:	Andere Fachgebiete
Genre:	Importe , Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Reihe:	Strungmann Forum Reports
Inhalt:	Einband - flex.(Paperback)
ISBN-13:	9780262547383
ISBN-10:	0262547384
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Redaktion:	Binder, Elisabeth Gordon, Joshua A.
Hersteller:	MIT Press Ltd Strungmann Forum Reports
Verantwortliche Person für die EU:	Libri GmbH, Europaallee 1, D-36244 Bad Hersfeld, gpsr@libri.de
Maße:	152 x 229 x 22 mm
Von/Mit:	Elisabeth Binder (u. a.)
Erscheinungsdatum:	10.10.2023
Gewicht:	0,454 kg