Preface Richard J. Pinder, Christopher James Harvey and Ellen Fallows; Part I. An Introduction: 1. What is lifestyle medicine? Ellen Fallows; 2. Paradigms in medicine and society Richard J. Pinder; 3. Global and historical perspectives in lifestyle medicine Rob Lawson and Ellen Fallows; Part II. Foundations in Lifestyle Medicine: 4. Understanding the evidence base Shyam Budhathoki and Richard J. Pinder; 5. Cellular level mechanisms Federica Amati and Lucy McCann; 6. The social determinants of health and health equity Angharad Kate Woolley; 7. Person-centred care Ollie Hart and Ellen Fallows; 8. Place, environment and planetary health Derek Clements-Croome; Part III. The Pillars of Lifestyle Medicine Practice: 9. Mental wellbeing Sam Manger; 10. Healthy relationships Mohanpal Singh Chandan and Vikesh Sharma; 11. Healthy eating Sumantra Ray, Breanna Lepre, Federica Amati, Veronica Funk Petric and Lauren Ball; 12. Physical activity Andrew Boyd; 13. Sleep Christopher-James Harvey; 14. Avoidance of harmful substances and behaviours Miriam Hillyard; Part IV. Skills Used in Lifestyle Medicine: 15. Behaviour and behaviour change Paul Chadwick; 16. Coaching and motivational interviewing Tim Antiss; 17. Brief advice and signposting Jack B. Joyce, Charlotte Albury and Paul Aveyard; 18. Social prescribing Alex Maxwell; 19. Supported self-care and health education Austen el Osta; 20. Group consultations and community-integrated care Emily Symington and Fraser Birrell; 21. Taking a lifestyle history Ellen Fallows and Niamh Louwman; 22. Deprescribing Daniel Okeowo, Beth Fylan and Anthony Avery; Part V. Transforming Medicine: 23. Workforce and physician health Shriti Pattani and Kevin Teoh; 24. Changing lifestyle through technology Maxine Whelan and Dale Esliger; 25. Clinicians as agents of change John Sykes.