Section A. Introduction and Evidence Base 1. Need for a Paradigm Shift: Gaps and Failures in Traditional Mental Health and Addiction Treatments 2. Digital Therapeutics: A New Class of Tools for Old Problems 3. State of the Science of Internet-Based Programs for Direct-to-Consumer Standalone Care for Mental Health and Addiction 4. State of the Science of Mental Health and Addiction Treatment Apps for Direct-to-Consumer Standalone Care (Second Wave of Scalable Digital Therapeutics) 5. Blending Digital Therapeutics with Traditional Treatments within the Healthcare System

Section B. The New Frontier 6. Using Advances in Technology to Identify Digital Biomarkers to Improve Passive Patient Monitoring 7. Receptivity of Mobile Health Interventions 8. Analytics for Adapting Interventions to Context Targeting Vulnerability and Receptivity 9. Digital Therapeutic Alliance 10. The First Wave of Conversational Agents: Chatbots Embedded within Smartphones and the Internet 11. The Second Wave of Conversational Agents: Voice Assistants within Everyday Objects and the Internet of Things

Section C. Import Considerations 12. Cultural Adaptations of Digital Therapeutics 13. Implementation, Business Models, and Regulation 14. Lessons Learned and Potential Pitfalls 15. Privacy and Security 16. Ethical Considerations of Digital Therapeutics 17. Design Considerations for Preparation, Optimization, Evaluation and Maintaining Digital Therapeutics 18. Futuristic Vision 10-20 Years Out