Part I: Gynecologic Cytopathology SECTION 1: OVERVIEW

4 Pap Test and Cervical Cancer Screening: History and Reporting Terminology Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 8 Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology Michael J. Thrall, MD and Debora A. Smith, CT(ASCP) 10 Specimen Adequacy in Cervicovaginal Cytology Dina R. Mody, MD and George G. Birdsong, MD

SECTION 2: BENIGN AND INFECTIOUS CONDITIONS

14 Normal Pap Test Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 16 Infectious and Other Organisms in Pap Tests Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 18 Nonneoplastic Findings, Mimics, and Artifacts Ekene I. Okoye, MD and Dina R. Mody, MD

SECTION 3: SQUAMOUS CELLABNORMALITIES AND MIMICS

28 Low-Grade Squamous Intraepithelial Lesion and Mimics Dina R. Mody, MD 30 High-Grade Squamous Intraepithelial Lesion and Mimics Dina R. Mody, MD and Ekene I. Okoye, MD 34 Atypical Squamous Cells of Undetermined Significance Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC and Dina R. Mody, MD 36 Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion Dina R. Mody, MD and Nikolaos Chantziantoniou, PhD, ART(CSMLS), CFIAC 38 Squamous Cell Carcinoma of Cervix, Variants and Mimics Dina R. Mody, MD

46 Endocervical Adenocarcinoma In Situ, Variants and Mimics Dina R. Mody, MD 52 Endocervical Adenocarcinoma, Variants and Mimics Dina R. Mody, MD 56 Adenocarcinoma, Gastric Type Dina R. Mody, MD 58 Endometrial Cancers: Usual Types, Variants, and Mimics Ekene I. Okoye, MD and Dina R. Mody, MD 64 Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS Dina R. Mody, MD 70 Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy Dina R. Mody, MD and Ekene I. Okoye, MD

74 Extrauterine Carcinomas and Presentations in Cervicovaginal Cytology Dina R. Mody, MD 76 Neuroendocrine Carcinoma of Cervix Dina R. Mody, MD 78 Other Uncommon Malignancies in Cervicovaginal Cytology Dina R. Mody, MD

84 HPV and Other Molecular Testing in Gynecologic Cytology Michael J. Thrall, MD

90 Directly Sampled Endometrial Cytology Yuko Sugiyama, MD, PhD, FIAC and Dina R. Mody, MD

96 Anal Cytology Michael J. Thrall, MD

Part II: Exfoliative Cytopathology

Specimen Types in Respiratory Cytology and Adequacy Criteria Michael J. Thrall, MD 102 Benign and Reactive Changes Michael J. Thrall, MD 106 PneumocystisPneumonia and Mimics Michael J. Thrall, MD 108 Fungal Organisms in Respiratory Cytology Michael J. Thrall, MD Parasitic Organisms in Respiratory Cytology Michael J. Thrall, MD 112 Viral Infections (Cytomegalovirus, Herpesvirus, and Others) Michael J. Thrall, MD 114 Mycobacteria and Other Bacterial Infections Michael J. Thrall, MD 116 Sarcoidosis and Other Immune-Related Conditions Michael J. Thrall, MD 118 Pulmonary Alveolar Proteinosis and Mimics Michael J. Thrall, MD Miscellaneous Findings, Including Contaminants Michael J. Thrall, MD 122 Adenocarcinoma Michael J. Thrall, MD 126 Squamous Cell Carcinoma Michael J. Thrall, MD 128 Small Cell Carcinoma Michael J. Thrall, MD Large Cell Neuroendocrine Carcinoma Michael J. Thrall, MD 132 Carcinoid and Atypical Carcinoid Michael J. Thrall, MD 134 Rare Benign and Low Malignant Potential Tumors Michael J. Thrall, MD 136 Rare Malignant Tumors Michael J. Thrall, MD 138 NUT Carcinoma Michael J. Thrall, MD 139 SMARCA4-Deficient Undifferentiated Tumor Michael J. Thrall, MD Pulmonary Lymphoma Michael J. Thrall, MD 142 Pulmonary Metastasis Michael J. Thrall, MD

146 Specimen Types in Gastrointestinal Cytology and Normal Cellular Components Blythe K. Gorman, MD 148 Parasitic Infections Blythe K. Gorman, MD Viral Infections Blythe K. Gorman, MD 152 Esophagitis and Barrett Esophagus Blythe K. Gorman, MD 154 Esophageal Adenocarcinoma Blythe K. Gorman, MD 156 Esophageal Squamous Cell Carcinoma Blythe K. Gorman, MD 158 Gastritis and Intestinal Metaplasia Blythe K. Gorman, MD Gastric Adenocarcinoma Blythe K. Gorman, MD 162 Gastric Lymphoma Blythe K. Gorman, MD 164 Ampulla/Bile Duct/Pancreatic Duct Reactive Changes Blythe K. Gorman, MD 166 Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma Blythe K. Gorman, MD 168 Colorectal Adenoma/Carcinoma Blythe K. Gorman, MD Neuroendocrine Tumor/Carcinoma Blythe K. Gorman, MD 172 Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors Blythe K. Gorman, MD

176 Normal Cerebrospinal Fluid and Contamination by Normal Elements Hidehiro Takei, MD Infectious Meningitis Hidehiro Takei, MD 182 Aseptic and Mollaret Meningitis Hidehiro Takei, MD 184 Subarachnoid Hemorrhage Hidehiro Takei, MD 186 Neurodegenerative Diseases Hidehiro Takei, MD 188 Primary Brain Tumors Hidehiro Takei, MD Leukemia and Lymphoma Hidehiro Takei, MD 192 Metastasis in Cerebrospinal Fluid Hidehiro Takei, MD

196 Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology Donna M. Coffey, MD and Michael J. Thrall, MD Infectious Conditions Donna M. Coffey, MD and Michael J. Thrall, MD 202 Autoimmune Diseases Donna M. Coffey, MD and Michael J. Thrall, MD 204 Malignant Effusion, Mesothelioma 208 Malignant Effusion, Carcinomas 212 Malignant Effusion, Sarcomas

Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

214 Lymphoid Effusions and Lymphomas Donna M. Coffey, MD and Michael J. Thrall, MD

216 Primary Effusion Lymphoma John M. Stewart, MD, PhD and Michael J. Thrall, MD

218 Endometriosis and Endosalpingiosis Donna M. Coffey, MD, Nour Sneige, MD, and Michael J. Thrall, MD

220 Ovarian Neoplasms Donna M. Coffey, MD and Michael J. Thrall, MD

222 Immunocytochemistry, Histochemistry, and Other Ancillary Techniques Donna M. Coffey, MD and Michael J. Thrall, MD

228 Normal Urinary Cytology, Specimen Types, and Reporting Terminology Michael J. Thrall, MD and Rose Anton, MD

232 Ileal Conduit Specimens Rose Anton, MD and Michael J. Thrall, MD

234 Noninfectious Benign Conditions Rose Anton, MD and Michael J. Thrall, MD

236 Infectious Benign Conditions Rose Anton, MD and Michael J. Thrall, MD

238 Reactive Urothelial Changes Rose Anton, MD and Michael J. Thrall, MD

240 Low-Grade Urothelial Lesions Rose Anton, MD and Michael J. Thrall, MD

241 Atypical Urothelial Cells Michael J. Thrall, MD

242 High-Grade Urothelial Dysplasia/Carcinoma/Carcinoma In Situ Rose Anton, MD and Michael J. Thrall, MD

244 Squamous Cell Carcinoma of Urinary Bladder Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

246 Adenocarcinoma of Urinary Bladder Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

248 Other Malignancies in Urinary Cytology Rose Anton, MD, Nour Sneige, MD, and Michael J. Thrall, MD

250 Renal Pelvic Cytology Blythe K. Gorman, MD and Michael J. Thrall, MD

252 Ancillary Testing, UroVysion, and Others Gene Landon, MD, Nancy P. Caraway, MD, and Michael J. Thrall, MD

Part III: Fine-Needle Aspiration, Superficial

256 Superficial Aspiration Technique Rose Anton, MD and Dina R. Mody, MD

260 Ultrasound-Guided Thyroid Fine-Needle Aspiration Paula J. Woodward, MD 266 Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy Dina R. Mody, MD 268 Adenomatous (Benign Follicular) Nodule Mojgan Amrikachi, MD and Dina R. Mody, MD 270 Chronic Lymphocytic/Hashimoto Thyroiditis Mojgan Amrikachi, MD and Dina R. Mody, MD 272 Granulomatous Thyroiditis Mojgan Amrikachi, MD and Dina R. Mody, MD 274 Graves Disease/Diffuse Toxic Goiter Mukul K. Divatia, MD and Dina R. Mody, MD 275 Pigmented Thyroid Lesions and Crystals Mukul K. Divatia, MD and Dina R. Mody, MD 276 Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Dina R. Mody, MD 280 Follicular Neoplasm/Suspicious for a Follicular Neoplasm Dina R. Mody, MD 284 Follicular Neoplasm, Oncocytic (Hürthle Cell) Type Mojgan Amrikachi, MD and Dina R. Mody, MD 286 Papillary Thyroid Carcinoma, Classic Subtype Mojgan Amrikachi, MD and Dina R. Mody, MD 290 Papillary Thyroid Carcinoma Subtypes Mojgan Amrikachi, MD and Dina R. Mody, MD 298 Medullary Thyroid Carcinoma Mojgan Amrikachi, MD and Dina R. Mody, MD 302 Poorly Differentiated Thyroid Carcinoma Susan L. Haley, MD and Dina R. Mody, MD 304 Anaplastic Thyroid Carcinoma Susan L. Haley, MD and Dina R. Mody, MD 306 Thyroid Lymphoma Susan L. Haley, MD and Dina R. Mody, MD 308 Metastatic Carcinoma to Thyroid Susan L. Haley, MD and Dina R. Mody, MD 310 Other Nonneoplastic and Neoplastic Thyroid Lesions Encountered on Thyroid FNA Mojgan Amrikachi, MD and Dina R. Mody, MD

318 Parathyroid Cyst, Adenoma, and Carcinoma Susan L. Haley, MD, Rose Anton, MD, and Dina R. Mody, MD

OVERVIEW 324 Lymph Node Aspiration: Indications, Techniques, and Reporting Rose Anton, MD and Dina R. Mody, MD 326 FNA Sample Prep and Triage in Evaluating Suspected Lymphoma John M. Stewart, MD, PhD and Savitri Krishnamurthy, MD

BENIGN, INFECTIOUS, AND REACTIVE HYPERPLASIA 328 Inflammatory and Reactive Lymphoid Hyperplasia Rose Anton, MD and Savitri Krishnamurthy, MD

330 Granulomatous Lymphadenitis, Infectious and Sarcoid Rose Anton, MD and Savitri Krishnamurthy, MD

334 Rosai-Dorfman Disease Rose Anton, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD

METASTATIC MALIGNANCIES 336 Metastatic Malignancies (Carcinoma, Melanoma) Rose Anton, MD and Dina R. Mody, MD

338 HPV-Positive Head and Neck Squamous Cell Carcinoma Mary R. Schwartz, MD and Dina R. Mody, MD

NODAL B-CELL LYMPHOMA 342 Small Lymphocytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD 344 Lymphoplasmacytic Lymphoma Nancy P. Caraway, MD, John M. Stewart, MD, PhD, and Savitri Krishnamurthy, MD...