Crossing the Boundaries of Life | Taschenbuch

Cover: 9780226819341 | Crossing the Boundaries of Life | Karl S. Matlin | Taschenbuch | 2022

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Sprache: Englisch

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Beschreibung

"The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cytologist, the Nobel laureate Gèunter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to synthesize proteins to theorize how proteins in the cell communicate spatially, an idea he called signal hypothesis. Over the next 20 years, Blobel and other scientists were able to dissect this process into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis-the idea that each protein in the cell is synthesized with an 'address' that directs the protein to its correct destination within the cell-Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel's investigative strategy and its subsequent application addressed the fundamental unresolved dilemma that had bedeviled biology from its very beginning, allowing biology to overcome the barrier that had long blocked progress toward mechanistic explanations of life. Crossing the Boundaries of Life thus uses Blobel's research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology"--

Über den Autor

Karl S. Matlin is professor emeritus of biological sciences and conceptual and historical studies of science at the University of Chicago.

Details

Erscheinungsjahr:	2022
Fachbereich:	Technik allgemein
Genre:	Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	Kartoniert / Broschiert
ISBN-13:	9780226819341
ISBN-10:	0226819345
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Matlin, Karl S.
Hersteller:	The University of Chicago Press
Maße:	225 x 151 x 21 mm
Von/Mit:	Karl S. Matlin
Erscheinungsdatum:	10.05.2022
Gewicht:	0,566 kg

Artikel-ID: 120755118

Über den Autor

Karl S. Matlin is professor emeritus of biological sciences and conceptual and historical studies of science at the University of Chicago.

Details

Erscheinungsjahr:	2022
Fachbereich:	Technik allgemein
Genre:	Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	Kartoniert / Broschiert
ISBN-13:	9780226819341
ISBN-10:	0226819345
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Matlin, Karl S.
Hersteller:	The University of Chicago Press
Maße:	225 x 151 x 21 mm
Von/Mit:	Karl S. Matlin
Erscheinungsdatum:	10.05.2022
Gewicht:	0,566 kg