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Classics in Total Synthesis III
Further Targets, Strategies, Methods
Buch von K. C. Nicolaou (u. a.)
Sprache: Englisch

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Beschreibung
Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou compiles here the important strategies and tools employed to construct complex molecules. For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces.
A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists.
Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou compiles here the important strategies and tools employed to construct complex molecules. For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces.
A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists.
Inhaltsverzeichnis
INTRODUCTION: THE ADVANCING FIELD OF TOTAL SYNTHESIS
Targets
Strategies and Methods
Classics in Total Synthesis III

TETRODOTOXIN
Introduction
Kishi's Retrosynthetic Analysis and Strategy
Kishi's Total Synthesis
Du Bois' Retrosynthetic Analysis and Strategy
Du Bois' Total Synthesis
Conclusion

DISCODERMOLIDE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

AZASPIRACID-1
Introduction
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis
Evans' Retrosynthetic Analysis and Strategy
Evans' Total Synthesis
Conclusion

THIOSTREPTON
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

PENTACYCLOANAMMOXIC ACID METHYL ESTER
Introduction
First-Generation Retrosynthetic Analysis and Strategy
First-Generation Total Synthesis
Second-Generation Retrosynthetic Analysis and Strategy
Second-Generation Total Synthesis
Conclusion

LITTORALISONE, OSELTAMIVIR (TAMIFLU®), AND HIRSUTELLONE B
Introduction
Introduction to Littoralisone
Total Synthesis of Littoralisone
Introduction to Oseltamivir (Tamiflu®)
Total Synthesis of Oseltamivir (Tamiflu®)
Introduction to Hirsutellone B
Total Synthesis of Hirsutellone B
Conclusion

RUBICORDIFOLIN AND RUBIONCOLIN B
Introduction
Retrosynthetic Analysis of Rubicordifolin
Total Synthesis of Rubicordifolin
Retrosyntheticd Analysis of Rubioncolin B
Total Synthesis of Rubioncolin B
Conclusion

CYANTHIWIGINS U AND F
Introduction
Phillips' Retrosynthetic Analysis and Strategy
Phillips' Total Synthesis
Stolz' Retrosynthetic Analysis and Strategy
Stoltz' Total Synthesis
Conclusion

STEPHACIDIN B
Introduction
Myers' Retrosynthetic Analysis and Strategy
Meyers' Total Synthesis
Baran's Retrosynthetic Analysis and Strategy
Baran's Total Synthesis
Williams' Retrosynthetic Analysis and Strategy
Williams' Total Synthesis
Conclusion

ABYSSOMICIN C AND ATROP-ABYSSOMICIN C
Introduction
Sorensen's Retrosynthetic Analysis and Strategy
Sorensen's Total Synthesis of Abyssomicin C
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis of Abyssomicin C and atrop-Abyssomicin C
Conclusion

TETRACYCLINE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

BISANTHRAQUINONE NATURAL PRODUCTS
Introduction
Retrosynthetic Analysis and Strategy Toward 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Total Synthesis of 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Retrosynthetic Analysis and Strategy Toward Antibiotic BE-43472B
Total Synthesis of Antibiotic BE-43472B
Conclusion

GARSUBELLIN A
Introduction
Sibasaki and Kanai's Retrosynthetic Analysis and Strategy
Shibasaki and Kanai's Total Synthesis
Danishefsky's Retrosynthetic Analysis and Strategy
Danishefsky's Total Synthesis
Conclusion

WELWITINDOLINONE A
Introduction
Baran's Retrosynthetic Analysis and Strategy
Barans' Total Synthesis
Wood's Retrosynthetic Analysis and Strategy
Wood's Total Synthesis
Conclusion

IEJIMALIDE B
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

KEDARCIDIN CHROMOPHORE AND MADUROPEPTIN CHROMOPHORE
Introduction
Retrosynthetic Analysis and Strategy for Kedarcidin Chromophore
Total Synthesis of Kedarcidin Chromophore
Retrosynthetic Analysis and Strategy for Maduropeptin Chromophore
Total Synthesis of Maduropeptin Chromophore
Conclusion

BIYOUYANAGIN A
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

AZADIRACHTIN
Introduction
Retrosynthetic Analysis and Strategy
Synthesis
Conclusion<
Details
Erscheinungsjahr: 2011
Fachbereich: Organische Chemie
Genre: Chemie, Mathematik, Medizin, Naturwissenschaften, Technik
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: XXIV
746 S.
26 farbige Illustr.
26 Illustr.
ISBN-13: 9783527329588
ISBN-10: 3527329587
Sprache: Englisch
Herstellernummer: 1132958 000
Autor: Nicolaou, K. C.
Chen, Jason S.
Auflage: 1. Auflage
Hersteller: Wiley-VCH
Verantwortliche Person für die EU: Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com
Abbildungen: 26 Farbabb.
Maße: 33 x 201 x 256 mm
Von/Mit: K. C. Nicolaou (u. a.)
Erscheinungsdatum: 15.02.2011
Gewicht: 1,87 kg
Artikel-ID: 133433199
Inhaltsverzeichnis
INTRODUCTION: THE ADVANCING FIELD OF TOTAL SYNTHESIS
Targets
Strategies and Methods
Classics in Total Synthesis III

TETRODOTOXIN
Introduction
Kishi's Retrosynthetic Analysis and Strategy
Kishi's Total Synthesis
Du Bois' Retrosynthetic Analysis and Strategy
Du Bois' Total Synthesis
Conclusion

DISCODERMOLIDE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

AZASPIRACID-1
Introduction
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis
Evans' Retrosynthetic Analysis and Strategy
Evans' Total Synthesis
Conclusion

THIOSTREPTON
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

PENTACYCLOANAMMOXIC ACID METHYL ESTER
Introduction
First-Generation Retrosynthetic Analysis and Strategy
First-Generation Total Synthesis
Second-Generation Retrosynthetic Analysis and Strategy
Second-Generation Total Synthesis
Conclusion

LITTORALISONE, OSELTAMIVIR (TAMIFLU®), AND HIRSUTELLONE B
Introduction
Introduction to Littoralisone
Total Synthesis of Littoralisone
Introduction to Oseltamivir (Tamiflu®)
Total Synthesis of Oseltamivir (Tamiflu®)
Introduction to Hirsutellone B
Total Synthesis of Hirsutellone B
Conclusion

RUBICORDIFOLIN AND RUBIONCOLIN B
Introduction
Retrosynthetic Analysis of Rubicordifolin
Total Synthesis of Rubicordifolin
Retrosyntheticd Analysis of Rubioncolin B
Total Synthesis of Rubioncolin B
Conclusion

CYANTHIWIGINS U AND F
Introduction
Phillips' Retrosynthetic Analysis and Strategy
Phillips' Total Synthesis
Stolz' Retrosynthetic Analysis and Strategy
Stoltz' Total Synthesis
Conclusion

STEPHACIDIN B
Introduction
Myers' Retrosynthetic Analysis and Strategy
Meyers' Total Synthesis
Baran's Retrosynthetic Analysis and Strategy
Baran's Total Synthesis
Williams' Retrosynthetic Analysis and Strategy
Williams' Total Synthesis
Conclusion

ABYSSOMICIN C AND ATROP-ABYSSOMICIN C
Introduction
Sorensen's Retrosynthetic Analysis and Strategy
Sorensen's Total Synthesis of Abyssomicin C
Nicolaou's Retrosynthetic Analysis and Strategy
Nicolaou's Total Synthesis of Abyssomicin C and atrop-Abyssomicin C
Conclusion

TETRACYCLINE
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

BISANTHRAQUINONE NATURAL PRODUCTS
Introduction
Retrosynthetic Analysis and Strategy Toward 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Total Synthesis of 2,2'-epi-Cytoskyrin A, Rugulosin, and Rugulin
Retrosynthetic Analysis and Strategy Toward Antibiotic BE-43472B
Total Synthesis of Antibiotic BE-43472B
Conclusion

GARSUBELLIN A
Introduction
Sibasaki and Kanai's Retrosynthetic Analysis and Strategy
Shibasaki and Kanai's Total Synthesis
Danishefsky's Retrosynthetic Analysis and Strategy
Danishefsky's Total Synthesis
Conclusion

WELWITINDOLINONE A
Introduction
Baran's Retrosynthetic Analysis and Strategy
Barans' Total Synthesis
Wood's Retrosynthetic Analysis and Strategy
Wood's Total Synthesis
Conclusion

IEJIMALIDE B
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

KEDARCIDIN CHROMOPHORE AND MADUROPEPTIN CHROMOPHORE
Introduction
Retrosynthetic Analysis and Strategy for Kedarcidin Chromophore
Total Synthesis of Kedarcidin Chromophore
Retrosynthetic Analysis and Strategy for Maduropeptin Chromophore
Total Synthesis of Maduropeptin Chromophore
Conclusion

BIYOUYANAGIN A
Introduction
Retrosynthetic Analysis and Strategy
Total Synthesis
Conclusion

AZADIRACHTIN
Introduction
Retrosynthetic Analysis and Strategy
Synthesis
Conclusion<
Details
Erscheinungsjahr: 2011
Fachbereich: Organische Chemie
Genre: Chemie, Mathematik, Medizin, Naturwissenschaften, Technik
Rubrik: Naturwissenschaften & Technik
Medium: Buch
Inhalt: XXIV
746 S.
26 farbige Illustr.
26 Illustr.
ISBN-13: 9783527329588
ISBN-10: 3527329587
Sprache: Englisch
Herstellernummer: 1132958 000
Autor: Nicolaou, K. C.
Chen, Jason S.
Auflage: 1. Auflage
Hersteller: Wiley-VCH
Verantwortliche Person für die EU: Wiley-VCH GmbH, Boschstr. 12, D-69469 Weinheim, product-safety@wiley.com
Abbildungen: 26 Farbabb.
Maße: 33 x 201 x 256 mm
Von/Mit: K. C. Nicolaou (u. a.)
Erscheinungsdatum: 15.02.2011
Gewicht: 1,87 kg
Artikel-ID: 133433199
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