Professor Ajay Vorais honorary professor of paediatric haematology at University of Sheffield and consultant paediatric haematologist at Sheffield Children's Hospital. His daily practice involves the care of children with a variety of malignant and non-malignant blood disorders. He has a special interest in childhood leukaemia and cord blood transplantation. He is chair of the UK NCRI childhood leukaemia sub-group and I-BFM ALL committee. He is chief investigator of childhood and infant ALL clinical trials and is involved with several research projects in this area. He is programme director of the Trent Regional Paediatric Haemopoeitic Stem Cell transplant service.

Exhaustively reviews current therapeutic strategies and applications of precision medicine in ALL treatment

Provides scientists and clinicians with state of the art knowledge to guide their research and clinical management

Written by an international multidisciplinary team of authors

Chapter 1Title: Epidemiology including genetic predispositionAuthors: Professor Richard Houlston [...] Institute of Cancer Research, Royal Marsden, London and Professor Martin Stanulla [...] Hannover University.Chapter 2Title: Clinical FeaturesAuthor: Dr Nicholas Goulden [...] Great Ormond Street Hospital, LondonChapter 3Title: Diagnostic flow cytometry and immunophenotypic classificationAuthor: Dr Dario Campana [...] National University of Singapore.Chapter 4Title: CytogeneticsAuthors: Professor Anthony Moorman [...] and Professor Christine Harrison [...] both at Leukaemia Cytogenetics Reference Laboratory, Newcastle University.Chapter 5Title: Molecular geneticsAuthors: Dr Charles Mullighan, St Jude¿s Hospital, Memphis, USAChapter 6Title: Pharmacology including pharmacokinetics, pharmacodynamics and pharmacogeneticsAuthor: Professor Mary Relling [...] St Jude¿s Hospital, Memphis, USAChapter 7Title: Minimal Residual DiseaseAuthor: Jacques Van Dongen [...] Rotterdam University, NLChapter 8Title: Treatment ¿ first lineAuthor: Ajay Vora [...] , Sheffield Children's NHS Trust, UKChapter 9Title: Treatment ¿ relapseAuthor: Vaskar Saha [...] , Manchester University, UKChapter 10Title: Treatment ¿ new drugsAuthor: Michel Zwaan [...] Rotterdam, NLChapter 11Title: Treatment ¿ immune based approachesAuthors: Antibodies ¿ Arend Von Stackelberg [...] , Charite Hospital, BerlinCellular therapy ¿ Persis Amrolia [...] Great Ormond Street Hospital, London, UKChapter 12Title: Supportive careAuthor: Deepa Bhojwani [...] UCLA, CA, USAChapter 13Title: Developing world perspectiveAuthor: Allen Yeoh