Section I. General Aspects 1. The use of cerebrospinal fluid in biomarker studies 2. The cerebrospinal fluid and barriers - anatomical and physiological considerations 3. More than a drainage fluid: the role of CSF in signalling in the brain and other effects on brain tissue 4. Dosing, collection and quality control issues in cerebrospinal fluid research using animal models

Section II. CSF Research in Particular Disease Entities and its Clinical Context 5. Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system 6. Cerebrospinal fluid in the dementias 7. Biomarkers in cerebrospinal fluid for synucleinopathies, tauopathies, and other neurodegenerative disorders 8. Cerebrospinal fluid in Creutzfeld-Jakob disease 9. Cerebrospinal fluid findings in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathies 10. Cerebrospinal fluid biomarkers of malignancies located in the central nervous system 11. Impaired cerebrospinal fluid pressure 12. Cerebrospinal fluid in acute and chronic infectious diseases 13. Vascular diseases and bleedings 14. Cerebrospinal fluid and brain extracellular fluid in severe brain trauma 15. Epilepsy 16. Primary headaches 17. Psychiatric syndromes other than dementia