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Beschreibung
Highlighting significant advancements in the roles of certain metal ions in the conformational changes and function of cellular proteins, this volume discusses the mechanisms involved in the transport of metal ions into and out of target cells, particularly epithelial cells. It explains the role of key biologically relevant divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals such as nickel, zinc, and chromium, the text also discusses a few environmentally relevant toxic divalent cations, including mercury, cadmium, and arsenic.
Highlighting significant advancements in the roles of certain metal ions in the conformational changes and function of cellular proteins, this volume discusses the mechanisms involved in the transport of metal ions into and out of target cells, particularly epithelial cells. It explains the role of key biologically relevant divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals such as nickel, zinc, and chromium, the text also discusses a few environmentally relevant toxic divalent cations, including mercury, cadmium, and arsenic.
Über den Autor

Rudolfs K. Zalups, PhD, trained as a fellow and instructor at the Mayo Clinic, Yale University School of Medicine, University of Maryland School of Medicine, and the University of Rochester School of Medicine and Dentistry. He is now a professor at the Mercer University School of Medicine in Macon, Georgia.
James Koropatnick, PhD, is a Distinguished Oncology Scientist, Director of the LRCP Cancer Research Laboratory Program, Director of the UWO/CIHR Strategic Training Program in Cancer Research and Technology Transfer, Assistant Director of the Lawson Health Research Institute, and a Full Professor in the UWO Department of Oncology with cross-appointments in the UWO Departments of Microbiology and Immunology, Physiology and Pharmacology, and Pathology. He is also the Chief Scientific Officer of Sarissa, Inc. (a biotech discovery company) and sits on the Advisory Boards of Critical Outcomes Therapeutics, Inc., ID Laboratories, Inc., and MedVax Pharma, Inc.

Inhaltsverzeichnis

Cellular Inorganic Chemistry Concepts and Examples. Molecular and Cellular Biology of Mercury in the Kidneys. Essential and Toxic Metal Transport in the Liver. Molecular and Cell Biology of Lead. Transport and Biological Impact of Manganese. Metallothionein and Metal Homeostasis. Cellular and Molecular Biology of Iron-Binding Proteins. The Regulatory and Signaling Functions of Zinc Ions in Human Cellular Physiology. Glutathione, Protein Thiols, and Metal Homeostasis. Ionic and Molecular Mimicry and the Transport of Metals. Heavy Metal Transport and Detoxification in Crustacean Gastrointestinal and Renal Epithelial Cells. Metals and Cell Adhesion Molecules. Iron Metabolism and Disease. Metal Influences on Immune Function.

Details
Erscheinungsjahr: 2018
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: Einband - flex.(Paperback)
ISBN-13: 9781138372658
ISBN-10: 113837265X
Sprache: Englisch
Einband: Kartoniert / Broschiert
Autor: Zalups, Rudolfs K.
Koropatnick, D. James
Hersteller: CRC Press
Verantwortliche Person für die EU: Libri GmbH, Europaallee 1, D-36244 Bad Hersfeld, gpsr@libri.de
Maße: 254 x 178 x 24 mm
Von/Mit: Rudolfs K. Zalups (u. a.)
Erscheinungsdatum: 10.09.2018
Gewicht: 0,826 kg
Artikel-ID: 133270841