When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause problems which contribute to patient trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions. This book describes the fundamental principles of this phenomenon and covers the development of relevant technologies and their applications in therapeutic devices. Aimed at academics, practitioners and graduate students this book makes a significant contribution to the newly emerging discipline of 'nanomedicine'.
When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause problems which contribute to patient trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions. This book describes the fundamental principles of this phenomenon and covers the development of relevant technologies and their applications in therapeutic devices. Aimed at academics, practitioners and graduate students this book makes a significant contribution to the newly emerging discipline of 'nanomedicine'.
Über den Autor
Syed A. M. Tofail is a Senior Research Fellow with the Materials and Surface Science Institute at the University of Limerick, Ireland. He has approximately 10 years experience in the development and characterisation of nano- and biomaterials. His major research accomplishment to date has been the determination of the correct crystal symmetry of hydroxyapatite, a leading synthetic biomaterial. This led him to discover piezoelectricity in synthetic hydroxyapatite. Experienced in the field of materials and surface science, Dr Tofail carries out fundamental research directed at the development of medical devices with new functionality. This involves working closely with the relevant industrial players. Dr Tofail is currently coordinating a European Commission Framework 7 project funded under the Nanotechnology, Materials and Processing (NMP) programme. One of the core objectives of this project is to develop MRSA-resistant medical textiles. In addition, the project aims to develop implantable devices for cardiovascular, orthopaedic and urinary applications.
Inhaltsverzeichnis
Electrostatic Charge on Biomaterials Surface; Electrical modifications of biomaterials' surfaces: Beyond hydrophobicity and hydrophilicity; Photocatalytic effects in doped and undoped titania; Surface charge measurements on biomaterials in dry and wet conditions Measurements of surface and interfacial charge and morphology in electrically modified materials; Protein Interactions at the surface; Immobilisation of enzymes on porous surface; Fibrous proteins interactions with modified surfaces of biomaterials; Antibody immobilisation on solid surfaces: methods and applications; Cellular Interactions with Abiotic Surfaces; Interactions of bone forming cells with electrostatic charge at biomaterials surface; Interactions of biofilm-forming bacteria with abiotic surfaces; Endothelial cells and smooth muscle cells (SMC) interactions at biomaterials surfaces; Interactions of Bacteria and fungi at the surface; Immunological response of electrostatic charge at the surface of biomaterials; IV. Applications; Community and hospital acquired Staphylococcal infections; MRSA resistant textiles; Inhibition of urological devices; Encrustation; Reduction of restenosis in cardiovascular stents; Regulatory and safety issues related to biomedical devices
