Bile Acids and Their Receptors | Buch

Cover: 9783030220044 | Bile Acids and Their Receptors | Eleonora Distrutti (u. a.) | Buch | x

Rückseite: 9783030220044 | Bile Acids and Their Receptors | Eleonora Distrutti (u. a.) | Buch | x

Dekorationsartikel gehören nicht zum Leistungsumfang.

Sprache: Englisch

147,95 €*

-8 % UVP 160,49 €

inkl. MwSt.

Versandkostenfrei per Post / DHL

Lieferzeit 1-2 Wochen

Kategorien:

Der Artikel ist nicht in deutscher Sprache verfasst.
Die Sprache der Produktbeschreibung und Details kann in Englisch angegeben sein. Sollten Sie Verständnisprobleme haben, wenden Sie sich gerne an uns.

Beschreibung

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

Zusammenfassung

Gives an overview on latest findings in the novel field of research of bile acids as signaling molecules

Offers a cross-country view of the functional role of bile acids as signaling molecules, virtuallyacting on all major areas of metabolism

Describes different approaches of bile acids pharmacology by providing authors' diverse perspectives

Inhaltsverzeichnis

Preface.- Part 1. Bile acids as signaling molecules and their receptors.- 1. A short history of bile acid pharmacology.- 2. Bile acids activated receptors: a review of GPBAR1 (TGR5) and other G-protein-coupled receptors.- 3. Bile acid activated receptors: a review of FXR and other Nuclear receptors.- 4. The intestinal enterokine fibroblast growth factor 15/19 in bile acid metabolism.- 5. Signaling from intestine to the host. How bile acids regulate intestinal and liver immunity.- Part 2. General pharmacology of bile acid activated receptors and their ligands.- 6. Modeling of bile acid activated receptors as a tool for pharmacological development.- 7. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists and antagonists.- 8. Non steroidal FXR ligands: current status and clinical applications.- 9. Intestinal selective FXR agonists and their potential in treating liver and metabolic diseases.- Part 3. Bile acids and their derivatives as drugs.- 10. UDCA, Nor-UDCA and T-UDCA: a review of their mechanisms of action and clinical applications.- 11. Chenodeoxycholic acid: an update on its therapeutic appplications and safety profile.- 12. Obeticholic acid: a review of its mechanisms of action and clinical applications.- Part 4. Bile acid activated receptors as therapeutic targets.- 13. Targeting FXR in cholestasis.- 14. FXR agonists for the treatment of NASH and other metabolic disorders.- 15. Targeting bile acids activated receptors in bariatric surgery.

Erscheinungsjahr:	2019
Fachbereich:	Toxikologie
Genre:	Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Wissenschaften
Medium:	Buch
Inhalt:	x 378 S. 20 s/w Illustr. 37 farbige Illustr. 378 p. 57 illus. 37 illus. in color.
ISBN-13:	9783030220044
ISBN-10:	3030220044
Sprache:	Englisch
Einband:	Gebunden
Redaktion:	Distrutti, Eleonora Fiorucci, Stefano
Herausgeber:	Stefano Fiorucci/Eleonora Distrutti
Auflage:	1st edition 2019
Hersteller:	Springer International Publishing
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	241 x 160 x 27 mm
Von/Mit:	Eleonora Distrutti (u. a.)
Erscheinungsdatum:	19.09.2019
Gewicht:	0,746 kg

Ähnliche Produkte