Basic Principles of Drug Discovery and Dev...

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Sprache: Englisch

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Beschreibung

Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Über den Autor

As an industrial medicinal chemist, Dr. Blass has experience with major pharmaceutical organizations (Wyeth, Procter & Gamble Pharmaceuticals) and small biotech operations (Fox Chase Chemical Diversity Center), which provided him with a wealth of expertise in the art of drug discovery and development (including a wide range of disease states and biological targets). His position with Temple University's School of Pharmacy and the Moulder Center for Drug Discovery has provided him with essential experience as an educator and academic scientist. These experiences, as well as his training and expertise as a registered US patent agent, have provided him with the tools and skills necessary to bridge the gap between industrial drug discovery and academic research.

Inhaltsverzeichnis

1. Drug Discovery and Development: An Overview of Modern Methods and Principles 2. The Drug Discovery Process: From Ancient Times to the Present Day 3. Classical Targets in Drug Discovery 4. In Vitro Screening Systems 5. Medicinal Chemistry 6. In vitro ADME and In vivo Pharmacokinetics 7. Animal Models of Disease States 8. Safety and Toxicology 9. Antibody Drug Discovery 10. Basics of Clinical Trials 11. Translational Medicine and Biomarkers 12. Organizational Considerations and Trends in the Pharmaceutical Industry 13. Intellectual Property and Patents in Drug Discovery 14. Case Studies in Drug Discovery

Erscheinungsjahr:	2021
Fachbereich:	Toxikologie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Taschenbuch
Seiten:	712
Inhalt:	Kartoniert / Broschiert
ISBN-13:	9780128172148
ISBN-10:	0128172142
Sprache:	Englisch
Herstellernummer:	C2017-0-02030-X
Einband:	Kartoniert / Broschiert
Autor:	Blass, Benjamin E.
Hersteller:	Elsevier Science Publishing Co Inc
Maße:	227 x 152 x 36 mm
Von/Mit:	Benjamin E. Blass
Erscheinungsdatum:	30.06.2021
Gewicht:	1,152 kg

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