Autophagy in Stem Cell Maintenance and Dif...

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Beschreibung

This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells.

Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.

Zusammenfassung

Provides a comprehensive knowledge on the regulation and role of autophagy in stem cells

Offers insights into the mechanisms of stem-cell self-renewal and differentiation

Covers complex aspects of autophagy in cancer stem cells with focus on therapy

Inhaltsverzeichnis

Assays for monitoring autophagy in stem cells.- Autophagy in Stem Cell Maintenance and Differentiation.- Autophagy in Embryonic stem cells and Neural stem cells.- Autophagy in Germline Stem Cells.- The role of autophagy in the regulation of hematopoietic stem cells.- Autophagy in Muscle Stem Cells.- Autophagy in Intestinal Stem Cells.- The autophagy lysosomal pathway: friend or foe in adult neural stem cells?.- Autophagy in Mesenchymal Stem Cell-based therapy.- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders.- Autophagy in Cancer Metastasis.

Details

Erscheinungsjahr:	2022
Fachbereich:	Therapie
Genre:	Medizin
Rubrik:	Wissenschaften
Medium:	Buch
Reihe:	Stem Cell Biology and Regenerative Medicine
Inhalt:	viii 288 S. 7 s/w Illustr. 34 farbige Illustr. 288 p. 41 illus. 34 illus. in color.
ISBN-13:	9783031173615
ISBN-10:	3031173619
Sprache:	Englisch
Ausstattung / Beilage:	HC runder Rücken kaschiert
Einband:	Gebunden
Redaktion:	Turksen, Kursad Shravage, Bhupendra V.
Herausgeber:	Bhupendra V Shravage/Kursad Turksen
Auflage:	1st ed. 2023
Hersteller:	Springer International Publishing Springer International Publishing AG Stem Cell Biology and Regenerative Medicine
Maße:	241 x 160 x 22 mm
Von/Mit:	Kursad Turksen (u. a.)
Erscheinungsdatum:	09.11.2022
Gewicht:	0,612 kg