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Englisch
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Beschreibung
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).
Über den Autor
A Dra. Prasanta Kumar Biswal está actualmente a trabalhar como Professora e Chefe do Departamento de Farmácia, Gayatri College of Pharmacy, Sambalpur, Odisha, Índia.O Dr. Prafulla Kumar Sahu, Ph.D. está a trabalhar como Professor Principal cum na Faculdade de Farmácia, Universidade de Tecnologia e Gestão do Centurião, Campus de Bolangir.
Details
| Erscheinungsjahr: | 2022 |
|---|---|
| Fachbereich: | Toxikologie |
| Genre: | Importe, Medizin |
| Rubrik: | Wissenschaften |
| Medium: | Taschenbuch |
| Inhalt: | Kartoniert / Broschiert |
| ISBN-13: | 9786205528082 |
| ISBN-10: | 6205528088 |
| Sprache: | Englisch |
| Einband: | Kartoniert / Broschiert |
| Autor: |
Biswal, Prasanta Kumar
Sahu, Prafulla Kumar |
| Hersteller: | LAP LAMBERT Academic Publishing |
| Verantwortliche Person für die EU: | preigu GmbH & Co. KG, Lengericher Landstr. 19, D-49078 Osnabrück, mail@preigu.de |
| Maße: | 220 x 150 x 5 mm |
| Von/Mit: | Prasanta Kumar Biswal (u. a.) |
| Erscheinungsdatum: | 29.12.2022 |
| Gewicht: | 0,131 kg |