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Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Supports the development of innovative cancer treatments through ADC techniques
Provides step-by-step methodologies that are readily reproducible
Features expert tips and key implementation advice to ensure successful results
Includes supplementary material: [...]
Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review.- Antibody-Drug Conjugate Target Selection: Critical Factors.- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization.- Antibody-Drug Conjugate Payloads.- Linker Technologies for Antibody-Drug Conjugates.- In VivoTesting of Drug-Linker Stability.- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates.- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment.- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting.- Protocols for Lysine Conjugation.- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.- Enzymatic Antibody Modification by Bacterial Transglutaminase.- Formulation Development of Antibody-Drug Conjugates.- Conjugation Process Development and Scale-Up.- Methods for Conjugating Antibodies to Nanocarriers.- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS.- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF.- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).
Erscheinungsjahr: | 2016 |
---|---|
Fachbereich: | Toxikologie |
Genre: | Importe, Medizin |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Inhalt: |
x
317 S. 54 s/w Illustr. 42 farbige Illustr. 317 p. 96 illus. 42 illus. in color. |
ISBN-13: | 9781493960262 |
ISBN-10: | 1493960261 |
Sprache: | Englisch |
Einband: | Kartoniert / Broschiert |
Redaktion: | Ducry, Laurent |
Herausgeber: | Laurent Ducry |
Auflage: | Softcover reprint of the original 1st edition 2013 |
Hersteller: | Humana Press |
Verantwortliche Person für die EU: | Humana Press in Springer Science + Business Media, Heidelberger Platz 3, D-14197 Berlin, juergen.hartmann@springer.com |
Maße: | 254 x 178 x 18 mm |
Von/Mit: | Laurent Ducry |
Erscheinungsdatum: | 23.08.2016 |
Gewicht: | 0,619 kg |
Supports the development of innovative cancer treatments through ADC techniques
Provides step-by-step methodologies that are readily reproducible
Features expert tips and key implementation advice to ensure successful results
Includes supplementary material: [...]
Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review.- Antibody-Drug Conjugate Target Selection: Critical Factors.- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization.- Antibody-Drug Conjugate Payloads.- Linker Technologies for Antibody-Drug Conjugates.- In VivoTesting of Drug-Linker Stability.- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates.- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment.- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting.- Protocols for Lysine Conjugation.- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.- Enzymatic Antibody Modification by Bacterial Transglutaminase.- Formulation Development of Antibody-Drug Conjugates.- Conjugation Process Development and Scale-Up.- Methods for Conjugating Antibodies to Nanocarriers.- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS.- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF.- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).
Erscheinungsjahr: | 2016 |
---|---|
Fachbereich: | Toxikologie |
Genre: | Importe, Medizin |
Rubrik: | Wissenschaften |
Medium: | Taschenbuch |
Inhalt: |
x
317 S. 54 s/w Illustr. 42 farbige Illustr. 317 p. 96 illus. 42 illus. in color. |
ISBN-13: | 9781493960262 |
ISBN-10: | 1493960261 |
Sprache: | Englisch |
Einband: | Kartoniert / Broschiert |
Redaktion: | Ducry, Laurent |
Herausgeber: | Laurent Ducry |
Auflage: | Softcover reprint of the original 1st edition 2013 |
Hersteller: | Humana Press |
Verantwortliche Person für die EU: | Humana Press in Springer Science + Business Media, Heidelberger Platz 3, D-14197 Berlin, juergen.hartmann@springer.com |
Maße: | 254 x 178 x 18 mm |
Von/Mit: | Laurent Ducry |
Erscheinungsdatum: | 23.08.2016 |
Gewicht: | 0,619 kg |