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Antibody-Drug Conjugates
Taschenbuch von Laurent Ducry
Sprache: Englisch

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Beschreibung
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular Biology¿ format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.
Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular Biology¿ format, these detailed chapters include the kind of practical implementation advice that guarantees quality results.
Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.
Zusammenfassung

Supports the development of innovative cancer treatments through ADC techniques

Provides step-by-step methodologies that are readily reproducible

Features expert tips and key implementation advice to ensure successful results

Includes supplementary material: [...]

Inhaltsverzeichnis

Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review.- Antibody-Drug Conjugate Target Selection: Critical Factors.- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization.- Antibody-Drug Conjugate Payloads.- Linker Technologies for Antibody-Drug Conjugates.- In VivoTesting of Drug-Linker Stability.- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates.- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment.- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting.- Protocols for Lysine Conjugation.- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.- Enzymatic Antibody Modification by Bacterial Transglutaminase.- Formulation Development of Antibody-Drug Conjugates.- Conjugation Process Development and Scale-Up.- Methods for Conjugating Antibodies to Nanocarriers.- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS.- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF.- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).

Details
Erscheinungsjahr: 2016
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: x
317 S.
54 s/w Illustr.
42 farbige Illustr.
317 p. 96 illus.
42 illus. in color.
ISBN-13: 9781493960262
ISBN-10: 1493960261
Sprache: Englisch
Einband: Kartoniert / Broschiert
Redaktion: Ducry, Laurent
Herausgeber: Laurent Ducry
Auflage: Softcover reprint of the original 1st edition 2013
Hersteller: Humana Press
Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, D-14197 Berlin, juergen.hartmann@springer.com
Maße: 254 x 178 x 18 mm
Von/Mit: Laurent Ducry
Erscheinungsdatum: 23.08.2016
Gewicht: 0,619 kg
Artikel-ID: 103477333
Zusammenfassung

Supports the development of innovative cancer treatments through ADC techniques

Provides step-by-step methodologies that are readily reproducible

Features expert tips and key implementation advice to ensure successful results

Includes supplementary material: [...]

Inhaltsverzeichnis

Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review.- Antibody-Drug Conjugate Target Selection: Critical Factors.- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization.- Antibody-Drug Conjugate Payloads.- Linker Technologies for Antibody-Drug Conjugates.- In VivoTesting of Drug-Linker Stability.- Pharmacokinetics and ADME Characterizations of Antibody-Drug Conjugates.- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment.- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting.- Protocols for Lysine Conjugation.- Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.- Enzymatic Antibody Modification by Bacterial Transglutaminase.- Formulation Development of Antibody-Drug Conjugates.- Conjugation Process Development and Scale-Up.- Methods for Conjugating Antibodies to Nanocarriers.- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatography.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS.- Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF.- Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).

Details
Erscheinungsjahr: 2016
Fachbereich: Toxikologie
Genre: Importe, Medizin
Rubrik: Wissenschaften
Medium: Taschenbuch
Inhalt: x
317 S.
54 s/w Illustr.
42 farbige Illustr.
317 p. 96 illus.
42 illus. in color.
ISBN-13: 9781493960262
ISBN-10: 1493960261
Sprache: Englisch
Einband: Kartoniert / Broschiert
Redaktion: Ducry, Laurent
Herausgeber: Laurent Ducry
Auflage: Softcover reprint of the original 1st edition 2013
Hersteller: Humana Press
Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, D-14197 Berlin, juergen.hartmann@springer.com
Maße: 254 x 178 x 18 mm
Von/Mit: Laurent Ducry
Erscheinungsdatum: 23.08.2016
Gewicht: 0,619 kg
Artikel-ID: 103477333
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