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Cover: 9783030738549 | Anoikis | Steven M. Frisch | Buch | HC runder Rücken kaschiert | viii
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Anoikis
How the Extracellular Matrix Regulates Life-or-Death Decisions
Buch von Steven M. Frisch
Sprache: Englisch

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Beschreibung
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.
Über den Autor
Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.
Zusammenfassung

Is the first to summarize the past 26 years of research in this field

Provides both mechanistic and translational information regarding anoikis, in a convenient format

Serves as a unique resource for cell-, molecular- and cancer biologists, as well as their students

Inhaltsverzeichnis
Preface
Introduction
Chapter 1 The intersection of anoikis resistance and fatty acid metabolism in cancer
Chapter 2 Anoikis resistance in melanoma
Chapter 3 Anoikis mediated by stress-activated MAPK signaling pathways
Chapter 4 Metabolic Regulation of Anoikis
Chapter 5 Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells
Chapter 6 Role of the nuclear receptors in anoikis
Chapter 7 The roles of anoikis in cervical cancer
Chapter 8 Shc and the control of small GTPase dynamics in cellular anchorage
Chapter 9 Anoikis and the Human Gut Epithelium in Health and Disease
Chapter 10 Epithelial cell extrusion: the prelude to anoikis
Chapter 11 Microtubule modifications and mitochondria: role in anoikis
Details
Erscheinungsjahr: 2021
Fachbereich: Therapie
Genre: Medizin
Rubrik: Wissenschaften
Medium: Buch
Inhalt: viii
202 S.
6 s/w Illustr.
202 p. 6 illus.
ISBN-13: 9783030738549
ISBN-10: 303073854X
Sprache: Englisch
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Frisch, Steven M.
Herausgeber: Steven M Frisch
Auflage: 1st ed. 2021
Hersteller: Springer International Publishing
Maße: 241 x 160 x 18 mm
Von/Mit: Steven M. Frisch
Erscheinungsdatum: 28.07.2021
Gewicht: 0,489 kg
Artikel-ID: 119724071
Über den Autor
Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.
Zusammenfassung

Is the first to summarize the past 26 years of research in this field

Provides both mechanistic and translational information regarding anoikis, in a convenient format

Serves as a unique resource for cell-, molecular- and cancer biologists, as well as their students

Inhaltsverzeichnis
Preface
Introduction
Chapter 1 The intersection of anoikis resistance and fatty acid metabolism in cancer
Chapter 2 Anoikis resistance in melanoma
Chapter 3 Anoikis mediated by stress-activated MAPK signaling pathways
Chapter 4 Metabolic Regulation of Anoikis
Chapter 5 Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells
Chapter 6 Role of the nuclear receptors in anoikis
Chapter 7 The roles of anoikis in cervical cancer
Chapter 8 Shc and the control of small GTPase dynamics in cellular anchorage
Chapter 9 Anoikis and the Human Gut Epithelium in Health and Disease
Chapter 10 Epithelial cell extrusion: the prelude to anoikis
Chapter 11 Microtubule modifications and mitochondria: role in anoikis
Details
Erscheinungsjahr: 2021
Fachbereich: Therapie
Genre: Medizin
Rubrik: Wissenschaften
Medium: Buch
Inhalt: viii
202 S.
6 s/w Illustr.
202 p. 6 illus.
ISBN-13: 9783030738549
ISBN-10: 303073854X
Sprache: Englisch
Ausstattung / Beilage: HC runder Rücken kaschiert
Einband: Gebunden
Redaktion: Frisch, Steven M.
Herausgeber: Steven M Frisch
Auflage: 1st ed. 2021
Hersteller: Springer International Publishing
Maße: 241 x 160 x 18 mm
Von/Mit: Steven M. Frisch
Erscheinungsdatum: 28.07.2021
Gewicht: 0,489 kg
Artikel-ID: 119724071
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