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Cover: 9780323992893 | A Pharmacology Primer | Terry P. Kenakin | Taschenbuch | Englisch
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A Pharmacology Primer
Techniques for More Effective and Strategic Drug Discovery
Taschenbuch von Terry P. Kenakin
Sprache: Englisch

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Beschreibung
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.
Über den Autor
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.
Inhaltsverzeichnis
1. What is Pharmacology?
2. How Different Tissues Process Drug Response
3. Drug-Receptor Theory
4. Pharmacological Assay Formats: Binding
5. Drug Targets and Drug-Target Molecules
6. Agonists: The Measurement of Affinity and Efficacy in Functional Assays
7. Orthosteric Drug Antagonism
8. Allosteric Modulation
9. The Optimal Design of Pharmacological Experiments
10. Pharmacokinetics
11. Safety Pharmacology
12. The Drug Discovery Process
13. Selected Pharmacological Methods
Details
Erscheinungsjahr: 2022
Fachbereich: Einzelne Wirtschaftszweige
Genre: Wirtschaft
Rubrik: Recht & Wirtschaft
Medium: Taschenbuch
Inhalt: Kartoniert / Broschiert
ISBN-13: 9780323992893
ISBN-10: 0323992897
Sprache: Englisch
Einband: Kartoniert / Broschiert
Autor: Kenakin, Terry P.
Hersteller: Elsevier Science & Technology
Maße: 275 x 214 x 40 mm
Von/Mit: Terry P. Kenakin
Erscheinungsdatum: 23.08.2022
Gewicht: 1,416 kg
Artikel-ID: 121359852
Über den Autor
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.
Inhaltsverzeichnis
1. What is Pharmacology?
2. How Different Tissues Process Drug Response
3. Drug-Receptor Theory
4. Pharmacological Assay Formats: Binding
5. Drug Targets and Drug-Target Molecules
6. Agonists: The Measurement of Affinity and Efficacy in Functional Assays
7. Orthosteric Drug Antagonism
8. Allosteric Modulation
9. The Optimal Design of Pharmacological Experiments
10. Pharmacokinetics
11. Safety Pharmacology
12. The Drug Discovery Process
13. Selected Pharmacological Methods
Details
Erscheinungsjahr: 2022
Fachbereich: Einzelne Wirtschaftszweige
Genre: Wirtschaft
Rubrik: Recht & Wirtschaft
Medium: Taschenbuch
Inhalt: Kartoniert / Broschiert
ISBN-13: 9780323992893
ISBN-10: 0323992897
Sprache: Englisch
Einband: Kartoniert / Broschiert
Autor: Kenakin, Terry P.
Hersteller: Elsevier Science & Technology
Maße: 275 x 214 x 40 mm
Von/Mit: Terry P. Kenakin
Erscheinungsdatum: 23.08.2022
Gewicht: 1,416 kg
Artikel-ID: 121359852
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